Activators & Inhibitors

Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 µM.

A sterol C14? demethylase inhibitor with an IC50 of 0.25 nM. Anti-fungal used to prevent serious fungal infections in people with a weakened ability to fight infection and to treat yeast infections.

A sterol C14? demethylase inhibitor with an IC50 of 0.25 nM. Anti-fungal used to prevent serious fungal infections in people with a weakened ability to fight infection and to treat yeast infections.

Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol activates sirtuin subtype 1 (SIRT-1). SIRT1 activation has been reported to inhibit tumorigenesis and tumor cell proliferation.

RGFP966 is specific for HDAC3, with an IC50 of 0.08 µM and no effective inhibition of any other HDAC at concentrations up to 15 µM.

RGFP966 is specific for HDAC3, with an IC50 of 0.08 µM and no effective inhibition of any other HDAC at concentrations up to 15 µM.

RGFP966 is specific for HDAC3, with an IC50 of 0.08 µM and no effective inhibition of any other HDAC at concentrations up to 15 µM.

Rocilinostat, also known as ACY-1215, is a selective HDAC6 inhibitor with IC50 of 5 nM. It is over 10-fold more selective for HDAC6 than HDAC1, 2, 3 (class I HDACs) with slight activity against HDAC8, and minimal activity against HDAC4, 5, 7, 9, 11, SIRT1, and SIRT2.

Rocilinostat, also known as ACY-1215, is a selective HDAC6 inhibitor with IC50 of 5 nM. It is over 10-fold more selective for HDAC6 than HDAC1, 2, 3 (class I HDACs) with slight activity against HDAC8, and minimal activity against HDAC4, 5, 7, 9, 11, SIRT1, and SIRT2.