Activators & Inhibitors

VER-155002 is a small molecule, ATP-derivative inhibitor of HSP70 (IC50 = 500 nM). The compound inhibits proliferation of several colon and breast cancer cell lines, induces caspase dependent apoptosis in BT474 cells and down regulates expression of Her2 and Raf-1 in HCT116 cells.

VER-155002 is a small molecule, ATP-derivative inhibitor of HSP70 (IC50 = 500 nM). The compound inhibits proliferation of several colon and breast cancer cell lines, induces caspase dependent apoptosis in BT474 cells and down regulates expression of Her2 and Raf-1 in HCT116 cells.

Vinpocetine, also known as Cavinton or ethyl apovincaminate, is a specific inhibitor of basal and calmodulin-activated PDE1. Also blocks voltage-gated Na+ channels.

Vinpocetine, also known as Cavinton or ethyl apovincaminate, is a specific inhibitor of basal and calmodulin-activated PDE1. Also blocks voltage-gated Na+ channels.

VX-765, also known as Belnacasan, is a novel Caspase-1 inhibitor being investigated for the treatment of epilepsy.

VX-765 is a novel Caspase-1 inhibitor being investigated for the treatment of epilepsy.

VX-765 is a novel Caspase-1 inhibitor being investigated for the treatment of epilepsy.

Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.

Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.