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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 71835 )

      • MRL-24

        Ref: 10-1365
        Sizes: 5 mg, 25 mg
        From: €91.00

        Activity: PPARγ partial agonist . Function/Pharmacology: Displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. Highly effective (30 nM) at blocking Cdk5-mediated phosphorylation of PPARγ. Cell permeable. Chemical Name: (S)-2-(3-((1-(4-Methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl)methyl)phenoxy)propanoic acid

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      • Stemolecule CHIR99021 (2 mg)

        Ref: 04-0004
        Sizes: 2 mg
        From: €377.00

        Stemolecule CHIR99021 (2 mg)

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      • C75

        Ref: T10657
        Sizes: 1 mg, 5 mg, 1 mL, 2 mg
        From: €47.00

        C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM).C75 increases CPT1 activity and reduces DIO.

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      • SM-164

        Ref: T12932L
        Sizes: 1 mg, 5 mg, 25 mg, 50 mg, 10 mg, 2 mg
        From: €136.00

        SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains (IC50: 1.39 nM). It acts as an extremely potent antagonist of XIAP.

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      • AZD5582

        Ref: T14378
        Sizes: 1 mg
        From: €56.00

        AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.

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      • NVP-2

        Ref: T16363
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL, 200 mg, 2 mg
        From: €57.00

        NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases (IC50: 0.584 μM, 0.706 μM, and 0.605 μM, respectively).

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      • Trazodone

        Ref: T22442
        Sizes: 25 mg, 50 mg, 1 mL
        From: €52.00

        Trazodone (AF-1161), a 5-HT 2A/2C receptor antagonist, is used as an antidepressant for treating major anxiety disorders and depressive disorder.

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      • Pomalidomide

        Ref: T2384
        Sizes: 1 g, 100 mg, 50 mg, 500 mg, 10 mg, 1 mL, 200 mg
        From: €60.00

        Pomalidomide (CC-4047) is an anti-angiogenic and immunomodulatory agent. Pomalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN) and is commonly used in the synthesis of PROTAC products.

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      • TOFA

        Ref: T3988
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 1 mL, 200 mg, 2 mg
        From: €37.00

        TOFA (MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).

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