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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 70846 )

      • NE 10790

        Ref: T16289
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 2 mg
        From: €40.00

        NE 10790 (Legacy Tebubio ref. 282T16289). NE 10790 (3-PEHPC) is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak anti-resorptive agent. Although NE10790 was a poor inhibitor of FPP synthase

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      • Rifapentine

        Ref: T1629
        Sizes: 25 mg, 100 mg, 50 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €54.00

        Rifapentine (Legacy Tebubio ref. 282T1629). Rifapentine (Rifapentinum) is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.

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      • NIK SMI1

        Ref: T16290
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €186.00

        NIK SMI1 (Legacy Tebubio ref. 282T16290). NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).

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      • NF157

        Ref: T16291
        Sizes: 5 mg
        Price Enquiry

        NF157 (Legacy Tebubio ref. 282T16291). NF157 significantly decreases the expression of metalloproteinase (MMP)-3, MMP-13, which can be used in the treatment of osteoarthritis (OA). NF157 is a highly selective nanomolar P2Y11 antagonist (pKi: 7.35). The IC50s are 463 nM, 1811 μM, 170 μM for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 μM), P2Y2 (Ki=28.9 μM), respectively.

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      • NFPS

        Ref: T16292
        Sizes: 50 mg, 10 mg
        From: €750.00

        NFPS (Legacy Tebubio ref. 282T16292). NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competitive glycine transporter-1 (GlyT1) inhibitor (IC50s: 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively).

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      • NGD-4715

        Ref: T16293
        Sizes: 25 mg, 100 mg, 50 mg
        From: €1,726.00

        NGD-4715 (Legacy Tebubio ref. 282T16293). NGD-4715 is a selective, orally active antagonist of melanin-concentrating hormone receptor 1 (MCHR1).

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      • NGP555

        Ref: T16294
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €81.00

        NGP555 (Legacy Tebubio ref. 282T16294). NGP555 is a modulator of γ-secretase.

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      • Tiopronin

        Ref: T1630
        Sizes: 1 g, 1 mL * 10 mM (in DMSO)
        From: €33.00

        Tiopronin (Legacy Tebubio ref. 282T1630). Tiopronin (Acadione), a sulfhydryl acylated derivative of glycine, leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.

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      • Sulbactam

        Ref: T1631
        Sizes: 100 mg, 50 mg, 500 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €44.00

        Sulbactam (Legacy Tebubio ref. 282T1631). Sulbactam (CP45899) is a semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabolism of other beta-lactam antibiotics by the enzyme. Combining this agent with a beta-lactamase susceptible antibiotic, such as penicillins or a cephalosporin, to treat infections caused by beta-lactamase producing organisms, results in a decreased turnover rate of the beta-lactamase sensitive antibiotic and enhances its antibacterial activity.

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