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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 70847 )

      • PF-03654746

        Ref: T16476
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg
        From: €288.00

        PF-03654746 (Legacy Tebubio ref. 282T16476). PF-03654746 is a selective antagonist of the histamine H3 receptor. PF-03654746 improves cognitive efficacy and disease-modifying effects in Alzheimer's disease. PF-03654746 can be used in studies about the treatment of allergic rhinitis.

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      • PF-03715455

        Ref: T16477
        Sizes: 5 mg
        From: €5,834.00

        PF-03715455 (Legacy Tebubio ref. 282T16477). PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respective IC50: 0.88 and 23 nM). PF-03715455 has the potential for the treatment of COPD.

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      • PF-04447943

        Ref: T16478
        Sizes: 1 mg, 5 mg, 25 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €35.00

        PF-04447943 (Legacy Tebubio ref. 282T16478). PF-04447943 (Edelinontrine) is a potent and selective phosphodiesterase 9A inhibitor with an IC50 of 12 nM, which is 78-fold more selective than that used for other PDE family members (IC50>1000 nM).PF-04447943 exhibits anti-inflammatory activity, attenuates inflammatory responses by inhibiting oxidative stress, inflammation, and modulating T-cell polarization, and may be useful for research on sickle cell anemia.

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      • PF-04937319

        Ref: T16479
        Sizes: 1 mg, 5 mg, 25 mg, 50 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €44.00

        PF-04937319 (Legacy Tebubio ref. 282T16479). PF-04937319 is an activator of glucokinase (EC50 =154.4  μM). PF-04937319 maintains glucose-lowering efficacy while mitigating the risk of hypoglycemia observed with many other glucokinase activators. PF-04937319 can be used in research on the treatment of type 2 diabetes mellitus.

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      • α-Vitamin E

        Ref: T1648
        Sizes: 50 mg, 1 mL * 10 mM (in DMSO)
        From: €44.00

        α-Vitamin E (Legacy Tebubio ref. 282T1648). α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.

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      • PF-04991532

        Ref: T16480
        Sizes: 2 mg
        From: €89.00

        PF-04991532 (Legacy Tebubio ref. 282T16480). PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM in human and rat, respectively.

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      • PF-04995274

        Ref: T16481
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €35.00

        PF-04995274 (Legacy Tebubio ref. 282T16481). PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E (Ki range of 0.15-0.46 nM). It also has an EC50 range of 0.59-0.65 nM for rat 5-HT4S/4L/4E (Ki of 0.30 nM for rat 5-HT4S).

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      • PF-05085727

        Ref: T16482
        Sizes: 2 mg
        From: €94.00

        PF-05085727 (Legacy Tebubio ref. 282T16482). PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11. PF-05085727 is an effective, selective and brain penetrant inhibitor of cGMP-dependent PDE2A (IC50=2 nM) .

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      • PF-05105679

        Ref: T16483
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 200 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €47.00

        PF-05105679 (Legacy Tebubio ref. 282T16483). PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.

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