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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 70846 )

      • Pivalopril

        Ref: T16544
        Sizes: 25 mg, 100 mg, 50 mg
        From: €1,726.00

        Pivalopril (Legacy Tebubio ref. 282T16544). Pivalopril, a novel orally active angiotensin-converting enzyme inhibitor, acts by blocking the conversion of angiotensin I to angiotensin II.

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      • Pivanex

        Ref: T16545
        Sizes: 1 g, 100 mg, 50 mg, 500 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €40.00

        Pivanex (Legacy Tebubio ref. 282T16545). Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.

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      • PK 11195

        Ref: T16546
        Sizes: 2 mg, 1 mL * 10 mM (in DMSO)
        From: €35.00

        PK 11195 (Legacy Tebubio ref. 282T16546). PK 11195 (RP 52028) is a TSPO ligand for neuroimaging that exhibits significant protection against CoCl2-induced alterations and can be used to study leishmaniasis.

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      • PK14105

        Ref: T16547
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €149.00

        PK14105 (Legacy Tebubio ref. 282T16547). PK14105 has been evaluated biologically as a potential radioligand for positron emission tomography (PET) studies targeting peripheral benzodiazepine binding sites (PBBS) receptors. When administered to rats with unilaterally lesioned striata, PK14105 was observed to quickly cross the blood-brain barrier, displaying significant radioactivity retention in the lesioned striatum, in contrast to the unlesioned striatum or cerebellar vermis. Additionally, PK14105 has the capability to inhibit receptor ligands, calcium channel ligands, and co-transporters in all salivary glands.

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      • PKF050-638

        Ref: T16548
        Sizes: 25 mg, 100 mg, 50 mg
        From: €1,726.00

        PKF050-638 (Legacy Tebubio ref. 282T16548). PKF050-638 inhibits the CRM1-mediated Rev nuclear export by disrupting CRM1-NES interaction. PKF050-638 is an effective and selective inhibitor of HIV-1 Rev (IC50=0.04 μM).

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      • PKI-166

        Ref: T16549
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €40.00

        PKI-166 (Legacy Tebubio ref. 282T16549). PKI-166 is an oral inhibitor of EGF-R tyrosine kinase (IC50:0.7 nM) that is both effective and selective. PKI-166 can effectively inhibit the growth and metastasis of various human cancer cells including pancreatic cancer.

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      • Ambrisentan

        Ref: T1655
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €35.00

        Ambrisentan (Legacy Tebubio ref. 282T1655). Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but has yet to be implicated in cases of clinically apparent acute liver injury.

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      • PKR-IN-C16

        Ref: T16550
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €41.00

        PKR-IN-C16 (Legacy Tebubio ref. 282T16550). PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. PKR-IN-C16 protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress.

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      • Pladienolide B

        Ref: T16551
        Sizes: 100 μg
        From: €394.00

        Pladienolide B (Legacy Tebubio ref. 282T16551). Pladienolide B is a potent spliceosome inhibitor, a macrolide isolated from Streptomyces obtusususus Mer-12, which targets the SF3B1 subunit of the spliceosome.Pladienolide B exerts its antitumor effects by inhibiting pre-mRNA splicing and inducing necrosis.Pladienolide B possesses antitumor activity and can be used to study leukemia and lymphoid tumors. Pladienolide B has antitumor activity and can be used to study leukemia and lymphoid tumors.

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