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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 70846 )

      • Belzutifan

        Ref: T16679
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €73.00

        Belzutifan (Legacy Tebubio ref. 282T16679). Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile.

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      • Vinblastine sulfate

        Ref: T1668
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €57.00

        Vinblastine sulfate (Legacy Tebubio ref. 282T1668). Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).

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      • PTC-028

        Ref: T16680
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €44.00

        PTC-028 (Legacy Tebubio ref. 282T16680). PTC-028 selectively suppresses cancer cells whereas normal cells remain unaffected. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. The depletion of BMI-1 by PTC-028 causes caspase-mediated apoptosis.

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      • Nesolicaftor

        Ref: T16681
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €111.00

        Nesolicaftor (Legacy Tebubio ref. 282T16681). Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.

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      • Pumaprazole

        Ref: T16682
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €96.00

        Pumaprazole (Legacy Tebubio ref. 282T16682). Pumaprazole (BY-841) is an antagonist of a reversible proton pump.

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      • Puromycin aminonucleoside

        Ref: T16684
        Sizes: 5 mg, 25 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €45.00

        Puromycin aminonucleoside (Legacy Tebubio ref. 282T16684). Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.

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      • Purpurogallin

        Ref: T16685
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €55.00

        Purpurogallin (Legacy Tebubio ref. 282T16685). Purpurogallin, a naturally occurring phenol extracted from Quercus spp. plants, exhibits potent xanthine oxidase inhibitory activity (IC50: 0.2 μM) and also possesses antioxidant and anti-inflammatory effects.

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      • Pyr10

        Ref: T16686
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €37.00

        Pyr10 (Legacy Tebubio ref. 282T16686). Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor that distinguishes between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells (IC50: 0.72 μM) and has an IC50 of 13.08 μM for store-operated Ca2+ entry in BRL-2H3 cells.

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      • Pyr3

        Ref: T16687
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 200 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: €35.00

        Pyr3 (Legacy Tebubio ref. 282T16687). Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).

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