Activators & Inhibitors

Activity: PKC inhibitor . Function/Pharmacology: Sphingosine is an inhibitor of protein kinase C (IC50 = 1-3 µM).1 It is abundant in cell membranes and is an important mediator in various biochemical pathways.2-4 Chemical Name: (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol

Activity: Glutathione peroxidase mimic . Function/Pharmacology: Novel nontoxic selenium-containing multifunctional antioxidant and anti-inflammatory agent1. Displays protective effects in reperfusion injury and stroke2. Excellent scavenger of peroxynitrite3. Acts as a glutathione peroxidase mimetic4. Cell permeable. Chemical Name: 2-Phenyl-1,2-benzisoselenazol-3(2H)-one

Activity: Antioxidant . Function/Pharmacology: Displays radical scavenging1, anti-inflammatory2 and amyloid- aggregation inhibition activities3. Acts as an agonist at GPR354. Chemical Name: 3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl

Activity: Serine protease inhibitor . Function/Pharmacology: TPCK is an irreversible inhibitor of the serine protease chymotrypsin.1 It also inhibits certain cysteine proteases (bromelain, ficin, papain).1 TPCK inhibited (IC50 = 5 µM) the mitogen-induced activation of pp70s6k, a mitogen-regulated serine/threonine kinase involved in the G1 to S phase transition of the cell cycle.2 Chemical Name: N-p-Tosyl-L-phenylalanine chloromethyl ketone

Activity: Cellular protectant . Function/Pharmacology: Broad sprectrun radio- and chemoprotective agent. Prevents chemotherapy-induced apoptosis, upregulates HIF-1α and restores transcriptional activity in specific p53 mutants. Chemical Name: S-2(3-Aminopropylamino)-ethylphosphothioic acid

Activity: SIRT1 activator . Function/Pharmacology: A naturally occurring resveratrol analog. Inhibits nonreceptor kinases Syk and Lyk (IC50 approximately 10 μM)1. Stimulates Sirt12. Chemical Name: 3,3’,4,5’-Tetrahydroxy-trans-stilbene

Activity: Angiotensin AT1 antagonist . Function/Pharmacology: Non-peptide angiotensin II receptor antagonist.1,2 Clinically useful antihypertensive agent.3 Inhibits collagen I synthesis.4 Induces SIRT1 expression and activity and reduces hepatic injury in a rat reduced-size orthotopic liver transplantation model.5 Displays neuroprotective effects along with nimesulide against chronic fatigue stress.6 Displays myocardial antifibrotic activity.7 Chemical Name: 2-Butyl-4-chloro-1-{[2’-(1H-tetrazol-5-yl)(1,1’-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol, potassium salt

Activity: Antioxidant-nonphenolic . Function/Pharmacology: MCI-186 is an antioxidant free radical scavenger used as a neuroprotective agent following acute brain ischemia and subsequent cerebral infarction.1,2 It also protects against MPTP-induced neurotoxicity in the Substantia Nigra.3 Chemical Name: 3-Methyl-1-phenyl-2-pyrazolin-5-one

Activity: Free radical scavenger . Function/Pharmacology: Radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, Inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in rat), and inhibits the release of inflammatory mediators from human leukocytes and mast cells (effective dose ~ 100 µM) Chemical Name: trans-4-(2-Amino-3,5-dibromobenzylamin)cyclohexane ∙ HCl