Chemicals

The Molecular Glue/PROTAC® Optimization Kit for CDK2/CDK9-Cereblon Binding is designed for the testing and profiling of Molecular Glues (MG) and PROTACs targeting CDK2 (cyclin dependent kinase 2) or CDK9 (cyclin dependent kinase 9) and Cereblon (CRBN). The Molecular Glue/PROTAC® Optimization Kit for CDK2/CDK9-Cereblon Binding comes in a convenient AlphaLISA® format, with enough PROTAC® buffer, purified CDK2/CyclinA2 and CDK9/CyclinK complexes, and CRBN for 384 reactions. This kit also contains the control PROTAC® (CDK2/9 Degrader) and CDK inhibitor FN-1501.The Molecular Glue/PROTAC® of interest is incubated with Cereblon (CRBN) and CDK2 or CDK9, bringing them into proximity. CRBN contains a FLAG-tag, which is recognized by anti-FLAG AlphaLISA™ acceptor bead. CDK contains a GST-tag that binds to the donor bead. Upon excitation of the donor bead, a singlet oxygen is generated by the bead. The singlet oxygen excites the acceptor bead, which emits light proportionally to the lev

Phos-tag™ SDS-PAGE can be performed to separate phosphorylated and non-phosphorylated proteins by mixing Phos-tag™ Acrylamide with acrylamide solution to allow for polymerization to occur.

Select-HA 50k is a hyaluronic acid (HA) preparation of uniform and narrow size distribution prepared by in vitro synthesis using recombinant Pasteurella multocida hyaluronan synthase. Select-HA 50k and Select-HA™ is a trademark of Hyalose LLC.BackgroundHyaluronic acid (HA) is a high molecular weight anionic polysaccharide (1 000-10 000 kD) composed of repeating disaccharides and is one of several glycosaminoglycan components of the extracellular matrix of connective tissue. Free HA is taken up by the liver where it is degraded and recycled. Data indicates a relationship between HA levels local inflammation and severity of many disease such as hepatitis B or C rheumatoid arthritis liver fibrosis etc.Storage-20 °C or below. Avoid frequent freeze-thaw aliquoting is recommended. Avoid contamination with microbes or HA-degrading enzymes.References1. Jing W.; DeAngelis P. L. Synchronized chemoenzymatic synthesis of monodisperse hyaluronan polymers. J Biol Chem 2004 279 (40) 4234

Select-HA 400k is a hyaluronic acid (HA) preparation of uniform and narrow size distribution prepared by in vitro synthesis using recombinant Pasteurella multocida hyaluronan synthase. Select-HA 400k and Select-HA™ is a trademark of Hyalose LLC.Hyaluronic acid (HA) is a high molecular weight anionic polysaccharide (1 000-10 000 kD) composed of repeating disaccharides and is one of several glycosaminoglycan components of the extracellular matrix of connective tissue. Free HA is taken up by the liver where it is degraded and recycled. Data indicates a relationship between HA levels local inflammation and severity of many disease such as hepatitis B or C rheumatoid arthritis liver fibrosis etc.Storage: -20 °C or below. Avoid frequent freeze-thaw aliquoting is recommended. Avoid contamination with microbes or HA-degrading enzymes.

Select-HA 500k is a hyaluronic acid (HA) preparation of uniform and narrow size distribution prepared by in vitro synthesis using recombinant Pasteurella multocida hyaluronan synthase1. Select-HA 500k and Select-HA™ is a trademark of Hyalose LLC.BackgroundHyaluronic acid (HA) is a high molecular weight anionic polysaccharide (1 000-10 000 kD) composed of repeating disaccharides and is one of several glycosaminoglycan components of the extracellular matrix of connective tissue. Free HA is taken up by the liver where it is degraded and recycled. Data indicates a relationship between HA levels local inflammation and severity of many disease such as hepatitis B or C rheumatoid arthritis liver fibrosis etc.Storage-20 °C or below. Avoid frequent freeze-thaw aliquoting is recommended. Avoid contamination with microbes or HA-degrading enzymes.References1. Jing W.; DeAngelis P. L. Synchronized chemoenzymatic synthesis of monodisperse hyaluronan polymers. J Biol Chem 2004 279 (40) 4

Select-HA 600k is a hyaluronic acid (HA) preparation of uniform and narrow size distribution prepared by in vitro synthesis using recombinant Pasteurella multocida hyaluronan synthase. Select-HA 600k and Select-HA™ is a trademark of Hyalose LLC.BackgroundHyaluronic acid (HA) is a high molecular weight anionic polysaccharide (1 000-10 000 kD) composed of repeating disaccharides and is one of several glycosaminoglycan components of the extracellular matrix of connective tissue. Free HA is taken up by the liver where it is degraded and recycled. Data indicates a relationship between HA levels local inflammation and severity of many disease such as hepatitis B or C rheumatoid arthritis liver fibrosis etc.Storage-20 °C or below. Avoid frequent freeze-thaw aliquoting is recommended. Avoid contamination with microbes or HA-degrading enzymes.References1. Jing W.; DeAngelis P. L. Synchronized chemoenzymatic synthesis of monodisperse hyaluronan polymers. J Biol Chem 2004 279 (40) 42

Biotinylated Select-HA 1000k is a hyaluronic acid (HA) preparation of uniform and narrow size distribution prepared by in vitro synthesis using recombinant Pasteurella multocida hyaluronan synthase. Each HA molecule is end-labeled (reducing terminus) with a single biotin. Biotinylated Select-HA 1000k and Select-HA™ is a trademark of Hyalose LLC.BackgroundHyaluronic acid (HA) is a high molecular weight anionic polysaccharide (1 000-10 000 kD) composed of repeating disaccharides and is one of several glycosaminoglycan components of the extracellular matrix of connective tissue. Free HA is taken up by the liver where it is degraded and recycled. Data indicates a relationship between HA levels local inflammation and severity of many disease such as hepatitis B or C rheumatoid arthritis liver fibrosis etc.Storage-20 °C or below. Avoid frequent freeze-thaw aliquoting is recommended. Avoid contamination with microbes or HA-degrading enzymes.References1.Jing W.; DeAngelis P. L. Sync

Biotinylated Select-HA 250k is a hyaluronic acid (HA) preparation of uniform and narrow size distribution prepared by in vitro synthesis using recombinant Pasteurella multocida hyaluronan synthase. Each HA molecule is end-labeled (reducing terminus) with a single biotin. Biotinylated Select-HA 250k and Select-HA™ is a trademark of Hyalose LLC.BackgroundHyaluronic acid (HA) is a high molecular weight anionic polysaccharide (1 000-10 000 kD) composed of repeating disaccharides and is one of several glycosaminoglycan components of the extracellular matrix of connective tissue. Free HA is taken up by the liver where it is degraded and recycled. Data indicates a relationship between HA levels local inflammation and severity of many disease such as hepatitis B or C rheumatoid arthritis liver fibrosis etc.Storage-20 °C or below. Avoid frequent freeze-thaw aliquoting is recommended. Avoid contamination with microbes or HA-degrading enzymes.References1.Jing W.; DeAngelis P. L. Synchr

Biotinylated Select-HA 50k is a hyaluronic acid (HA) preparation of uniform and narrow size distribution prepared by in vitro synthesis using recombinant Pasteurella multocida hyaluronan synthase. Each HA molecule is end-labeled (reducing terminus) with a single biotin. Biotinylated Select-HA 50k and Select-HA™ is a trademark of Hyalose LLC.BackgroundHyaluronic acid (HA) is a high molecular weight anionic polysaccharide (1 000-10 000 kD) composed of repeating disaccharides and is one of several glycosaminoglycan components of the extracellular matrix of connective tissue. Free HA is taken up by the liver where it is degraded and recycled. Data indicates a relationship between HA levels local inflammation and severity of many disease such as hepatitis B or C rheumatoid arthritis liver fibrosis etc.Storage-20 °C or below. Avoid frequent freeze-thaw aliquoting is recommended. Avoid contamination with microbes or HA-degrading enzymes.References1.Jing W.; DeAngelis P. L. Synchron