Skip to main content
Customer Service: +31 072-572 21 00
Contact us
(0)
My Wishlist
(0)
My Wishlist
(0)
My WishlistContact us
Products banner

Chemicals

Filters

    Results for Chemicals ( 21791 )

      • PROTAC BRD4 Degrader-5

        Ref: T36242
        Sizes: 1 mg, 5 mg, 25 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        Price Enquiry

        PROTAC BRD4 Degrader-5 (Legacy Tebubio ref. 282T36242). PROTAC BRD4 Degrader-5 is a PROTAC that efficiently degrades BRD4 in HER2-positive and -negative breast cancer cell lines, and is formed by linking von Hippel-Lindau ligand to BRD4 ligand.

        Product detail

      • PROTAC RIPK degrader-6

        Ref: T36243
        Sizes: 5 mg, 25 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        Price Enquiry

        PROTAC RIPK degrader-6 (Legacy Tebubio ref. 282T36243). PROTAC RIPK degrader-6 (example 1) is a PROTAC engineered for RIP Kinase degradation, comprising a RIP2 kinase inhibitor linked to a cereblon binder[1].

        Product detail

      • TBK1 control PROTAC® 4

        Ref: T36247
        Sizes: 5 mg
        From: €1,215.00

        TBK1 control PROTAC® 4 (Legacy Tebubio ref. 282T36247). Negative control for TBK1 PROTAC 3i. Binds TBK1 with high affinity, but exhibits no significant degradation of TBK1. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

        Product detail

      • PROTAC BRD4 Degrader-8

        Ref: T36628
        Sizes: 1 mg, 5 mg
        Price Enquiry

        PROTAC BRD4 Degrader-8 (Legacy Tebubio ref. 282T36628). PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor with IC50 values of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively, effectively degrading the BRD4 protein in PC3 prostate cancer cells[1].

        Product detail

      • PROTAC IDO1 Degrader-1

        Ref: T37329
        Sizes: 5 mg
        Price Enquiry

        PROTAC IDO1 Degrader-1 (Legacy Tebubio ref. 282T37329). PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the ubiquitin-proteasome system (UPS) with a DC50 of 2.84 μM. This compound also moderately enhances the tumor-killing efficacy of HER2 CAR-T cells[1].

        Product detail

      • PROTAC BET Degrader-10

        Ref: T39374
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        Price Enquiry

        PROTAC BET Degrader-10 (Legacy Tebubio ref. 282T39374). PROTAC BET Degrader-10 (WO2017007612A1, example 37) is a highly efficient and selective small molecule compound designed to degrade BET protein BRD4. PROTAC BET Degrader-10 functions by utilizing specific ligands that connect Cereblon and BRD4, with a DC 50 value of 49 nM.

        Product detail

      • PROTAC ERRα Degrader-3

        Ref: T39837
        Sizes: 5 mg, 25 mg, 50 mg, 10 mg
        Price Enquiry

        PROTAC ERRα Degrader-3 (Legacy Tebubio ref. 282T39837). PROTAC ERRα Degrader-3 is a highly effective and selective von Hippel-Lindau-based ligand that efficiently degrades the ERRα protein, reducing its levels by >80% at a concentration of 30 nM. Notably, this compound shows no activity against the ERRβ and ERRγ proteins.

        Product detail

      • PROTAC CDK9 degrader 4

        Ref: T39996
        Sizes: 1 mg, 5 mg, 25 mg, 10 mg
        From: €366.00

        PROTAC CDK9 degrader 4 (Legacy Tebubio ref. 282T39996). PROTAC CDK9 degrader 4 is a highly potent CDK9 degrader that targets transcriptional regulation and has potential anticancer activity for the study of acute myelogenous leukemia (AML).

        Product detail

      • PROTAC PD-1/PD-L1 degrader-1

        Ref: T40112
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg
        From: €288.00

        PROTAC PD-1/PD-L1 degrader-1 (Legacy Tebubio ref. 282T40112). PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It restores the suppressed immune response in a co-culture model of Hep3B/OS-8/hPD-L1 cells and CD3 T cells and moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.

        Product detail