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      • Ref: F-H100
        Sizes: 100 mg
        From: €381.00

        Biliverdin Hydrochloride is produced from the oxidation of heme in a reaction catalyzed by the enzyme heme oxygenase. Heme oxygenase has been implicated in tumor cell resistance to chemotherapy reduction of free radical formation reduction of inflammation and has been associated with vascular repair. In vivo biliverdin is reduced to bilirubin. Biliverdin Hydrochloride is soluble in basic aqueous solutions (pH > 9 for intitial dissolution) and soluble down to pH 7 once in solution as well as methanol and ethanol if made slightly basic.References1) Seta F. L. Bellner et al. (2006). "Heme Oxygenase-2 Is a Critical Determinant for Execution of an Acute Inflammatory and Reparative Response." The American Journal of Pathology 169(5): 1612.2) Jozkowicz A. H. Was et al. (2007). "Heme oxygenase-1 in tumors: is it a false friend?" Antioxid Redox Signal 9(12): 2099-117.3) Abraham N. G. and A. Kappas (2005). "Heme oxygenase and the cardiovascular-renal system." Free Radic Biol Med 39

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      • Ref: F-H110
        Sizes: 25 mg, 10 mg
        From: €317.00

        Bilirubin dimethyl ester is a natural derivative of bilirubin and is found in normal sera representing an average of 1.75% total sera bilirubin. Bilirubin is a water insoluble tetrapyrrole produced from the reduction of biliverdin in a reaction catalyzed by the enzyme bilirverdin reductase. Water insoluble bilirubin (also called indirect bilirubin) in vivo undergoes glucuronidation in the liver (addition of one or two glucuronic acids through a glycosidic bond) to form the water soluble bilirubin mono or diglucuronide (also called bilirubin conjugate or direct bilirubin).  Bilirubin conjugate is excreted from the liver in bile or is converted to urobilinogen and excreted in the urine as urobilin or in the feces as stercobilin.  Bilirubin dimethyl ester has been found to be converted to bilirubin conjugate via esterase and glucuronidase activity in vivo.References1) Muraca M. and N. Blanckaert (1983). "Liquid-chromatographic assay and identification of mono- and diester conjugates of

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      • Ref: F-H120
        Sizes: 1G
        From: €299.00

        Bilirubin is a water insoluble tetrapyrrole produced from the reduction of biliverdin in a reaction catalyzed by the enzyme bilirverdin reductase. In vivo it undergoes glucuronidation in the liver (addition of one or two glucuronic acids through a glycosidic bond) to form the water soluble mono or diglucuronide (also called bilirubin conjugate). The conjugate is excreted from the liver in bile or is converted to urobilinogen and excreted in the urine as urobilin or in the feces as stercobilin.References1) Lee K. S. L. D. Raymond et al. (2007). "Hemin Interactions and Alterations of the Subcellular Localization of Prion Protein." Journal of Biological Chemistry 282(50): 36525-36533.2) Soares M. P. M. P. Seldon et al. (2004). "Heme Oxygenase-1 Modulates the Expression of Adhesion Molecules Associated with Endothelial Cell Activation." The Journal of Immunology 172(6): 3553-3563.3) Huber A. H. B. Zhu et al. (2012). "Fluorescence Sensor for the Quantification of Unbound Bilirubin

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      • Ref: F-H130
        Sizes: 1G, 100 mg
        From: €189.00

        Bilirubin Conjugate is a water soluble ditaurate derivative of bilirubin equivalent to bilirubin glucuronide derivatives. Bilirubin glucuronide derivatives are produced in vivo from the glucuronidation (addition of one or two glucuronic acids through a glycosidic bond) of bilirubin (also called indirect bilirubin) in a reaction catalyzed by the enzyme UDP Glucuronidase. The glucuronidation of bilirubin occurs in the liver to form the water soluble bilirubin mono or diglucuronide (also called bilirubin conjugate or direct bilirubin). Bilirubin conjugate is excreted from the liver in bile or is converted to urobilinogen and excreted in the urine as urobilin or in the feces as stercobilin.References1) Maghzal G. J. M.-C. Leck et al. (2009). "Limited Role for the Bilirubin-Biliverdin Redox Amplification Cycle in the Cellular Antioxidant Protection by Biliverdin Reductase." Journal of Biological Chemistry 284(43): 29251-29259.2) MacLean P. D. E. C. Drake et al. (2007). "Bilirubin as a

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      • Ref: F-H140
        Sizes: 5 mg, 10 mg
        From: €1,123.00

        Urobilin Hydrochloride is produced via the oxidation of urobilinogen a degradation product of bilirubin and excreted in the urine. Bilirubin is a water insoluble tetrapyrrole produced from the reduction of biliverdin in a reaction catalyzed by the enzyme bilirverdin reductase. Water insoluble bilirubin (also called indirect bilirubin) in vivo undergoes glucuronidation in the liver (addition of one or two glucuronic acids through a glycosidic bond) to form the water soluble bilirubin mono or diglucuronide (also called bilirubin conjugate or direct bilirubin). Bilirubin conjugate is excreted from the liver in bile or is converted to mesobilinogen via gut bacteria and then to urobilinogen and excreted in the urine as urobilin or stercobilinogen and excreted in the feces as stercobilin. Urobilin Hydrochloride is soluble in basic aqueous solutions (pH > 9 for intitial dissolution) and soluble down to pH 7 once in solution as well as methanol and ethanol if made slightly basic.Reference

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      • Ref: F-H150
        Sizes: 5 mg, 10 mg
        From: €327.00

        Stercobilin Hydrochloride is produced via the oxidation of stercobilinogen a degradation product of bilirubin and excreted in the feces. Bilirubin is a water insoluble tetrapyrrole produced from the reduction of biliverdin in a reaction catalyzed by the enzyme bilirverdin reductase. Water insoluble bilirubin (also called indirect bilirubin) undergoes glucuronidation in the liver (addition of one or two glucuronic acids through a glycosidic bond) to form the water soluble bilirubin mono or diglucuronide (also called bilirubin conjugate or direct bilirubin). Bilirubin conjugate is excreted from the liver in bile or is converted to mesobilinogen via gut bacteria and then to urobilinogen and excreted in the urine as urobilin or stercobilinogen and excreted in the feces as stercobilin. Stercobilin Hydrochloride is soluble in basic aqueous solutions (pH > 9 for initial dissolution) and soluble down to pH 7 once in solution as well as methanol and ethanol if made slightly basic.Reference

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      • Ref: F-H160
        Sizes: 25 mg, 50 mg
        From: €898.00

        Mesobiliverdin IX is an analog of biliverdin which occurs naturally in non-vertebrates and by bacterial transformation of non-conjugated bilirubin in mammals. Biliverdin has been proposed as a treatment for acute and chronic inflammation conditions such as diabetes but until recently it had been limited by scalable production and contamination of other isomers in animal sourced material. Mesobiliverdin is a substrate for bilverdin reductase and has recently been produced in scalable quantities from phycocyanobilin derived from cyanobacteria. Treatment of pancreata with Mesobiliverdin (1-100 μM) increased functional islet production up to 86% over non-treated controls. Transplantation of mesobiliverdin produced islets into STZ inducible diabetic rats lowered non-fasting blood glucose levels in 55% of subjects (22% for control) indicating recovery of insulin-dependant function.References1) T. Ito et al. “Mesobiliverdin IXa enhances pancreatic islet yield and production” Front. Pharm

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      • Ref: F-HOIT
        Sizes: EA PK
        From: €986.00

        The Heme Oxygenase Inhibitor Toolkit contains three inhibitors to heme oxygenase and a negative control [Cu (II) Protoporphyrin IX]. Heme Oxygenase catalyzes the conversion of heme to biliverdin in the heme degradation pathway and has been implicated in tumor cell resistance to chemotherapy reduction of free radical formation and inflammation and is associated with vesicular repair.Heme Oxygenase Inhibitor Toolbox contains:Zn (II) Protoporphyrin IX (F-H060) 100 mgCu (II) Protoporphyrin IX (F-H070) 50 mgSn (IV) Protoporphyrin IX Dichloride (F-H080) 250 mgZn (II) Deuteroepophyrin IX 2 4 bis ethylenglycol (F-H090) 25 mgStorageThe components of the Heme Oxygenase Inhibitor Kit stable for at least one year when stored as a solid protected from moisture at -20 °C. Protect from light.

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      • From: €348.00

        The Collagen Hybridizing Peptides are products of 3-Helix Inc.The collagen hybridizing peptide (CHP) is a novel and unique peptide that specifically binds unfolded collagen chains both in vitro and in vivo [1 2 3]. By sharing the Gly-X-Y repeating sequence of natural collagen CHP has a strong capability to hybridize with denatured collagen chains by reforming the triple helical structure in a fashion similar to DNA fragments annealing to complementary DNA strands. CHP is extremely specific: it has negligible affinity to intact collagen molecules due to lack of binding sites and it is inert towards non-specific binding because of its neutral and hydrophilic nature.CHP is a powerful histopathology tool which enables straightforward detection of inflammation and tissue damage caused by a large variety of diseases as well as tissue remodeling during development and aging [3]. CHP robustly visualizes the pericellular matrix turnover caused by proteolytic migration of cancer cells withi

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