Click Chemistry

SiR-NHS ester is the N-hyroxysuccinimidyl ester of SiR. This amine reactive probe enables the preparation of custom SiR probes. SiR-NHS ester can be coupled to any amine bearing ligand: antibody, drug, protein or nucleic acid. SiR is compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with standard Cy5 filtersets.

SiR-NHS ester is the N-hyroxysuccinimidyl ester of SiR. This amine reactive probe enables the preparation of custom SiR probes. SiR-NHS ester can be coupled to any amine bearing ligand: antibody, drug, protein or nucleic acid. SiR is compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with standard Cy5 filtersets.

SiR-tetrazine is a clickable derivative of SiR. This probe reacts with dienophiles such as trans-cyclooctene (TCO) or bicyclononyne (BCN) derivatives, enabling the preparation of custom SiR probes and conjugates. SiR-tetrazine is particularly useful in combination with unnatural amino acid (UAA) incorporation to prepare site selective protein conjugates. SiR-tetrazine is cell permeable and fluorogenic, it can be used to stain live cells as well as fixed ones. SiR is compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with a standard Cy5 filterset.

SiR-azide is the 3-azidopropyl derivative of the fluorophore silicon rhodamine (SiR). Sir-azide reacts with terminal alkyne derivatives in the presence of copper (I) to form 1,2,3-triazoles linkage. It can also react with strained alkynes such as DIFO or DIBO without the need of copper. Small molecules, peptides, oligonucleotides or proteins bearing the appropriate alkyne can be conjugated to SiR-azide. SiR-azide is compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with a standard Cy5 filterset.

SiR-alkyne is the N-propargylcarboxamide derivative of the fluorophore silicon rhodamine (SiR). Sir-alkyne reacts with azide derivatives in the presence of copper (I) to form 1,2,3-triazoles linkage. Small molecules, peptides, oligonucleotides or proteins bearing the appropriate azide can be conjugated to SiR-alkyne. SiR excitation and emission are compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with a standard Cy5 filterset.

SiR-maleimide is the 2-maleimidoethyl derivative of the fluorophore silicon rhodamine (SiR). SiR-maleimide reacts with thiols to form covalent conjugates. Small molecules, peptides, oligonucleotides or proteins bearing a free thiol can be conjugated to SiR-maleimide. SiR excitation and emission are compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with a standard Cy5 filterset.

SiR-BCN is a bicyclo[6.1.0]nonyne (BCN) derivative of the fluorophore silicon rhodamine (SiR). SiR-BCN contains a short PEG linker between the SiR fluorophore and the BCN moiety. SiR-BCN reacts quickly with tetrazine and azide derivatives to form covalent linkages. Small molecules, peptides, oligonucleotides or proteins bearing the appropriate tetrazine or azide can be conjugated to SiR-BCN. SiR excitation and emission are compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with a standard Cy5 filterset.

Doxorubicin Hydrochloride is the hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-Fmoc-N'-(azido-PEG4)-L-Lysine is a crosslinker containing one Fmoc protected amine, an azide group and a lysine. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.