Results for Click Chemistry ( 996 )
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Boc-Val-Cit-PAB-PNB is a cleavable peptide ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell.PNP can be substituted by amine bearing molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Gly-Gly-Gly-PEG3-methyltetrazine is a reagent featuring three glycine residues, a hydrophilic PEG spacer, and a methyltetrazine group. Methyltetrazine is a click chemistry handle which is used to efficiently react with trans-cyclooctenes (TCO). The N-terminal of the glycine tripeptide is free to perform a variety of reactions such as couplings with carboxylic acids or NHS esters.
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Mal-PEG8-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains a maleimide PEG8 moiety, a protease-sensitive Val-Cit dipeptide, a PABC linker and a MMAE payload. The MMAE is a synthetic antineoplastic agent. Mal is reactive with thiol group of antibody. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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N-(Iodoacetamido)-Doxorubicin is an iodine attached Doxorubicin. It can conjugate with molecules containing thiol, amine… functional groups. Doxorubicin is an anthracycline antibiotic with antineoplastic activity Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Mal-PEG1-Val-Cit-PAB-PNP is a cleavable peptide linker. The Val-Cit was designed to be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups at pH 6.5 to 7.5. PNP is a good leaving group. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.