Click Chemistry

Mal-amido-PEG8-val-gly-PAB-OH is a reagent featuring a maleimide, a hydrophilic PEG spacer, a Val-Gly dipeptide, and a PAB group with its free benzylic alcohol. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads, while the maleimide is used to covalently bind free thiols on the cysteine residues of proteins. The Val-Gly dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.

BCN-PEG3-VC-PFP Ester is a cleavable ADC linker featuring a BCN group, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PFP ester. The PFP ester is activated towards nucleophilic attack from amines, while BCN is a click chemistry handle which readily forms stable triazoles with azide groups on a target molecule. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery.

Val-Cit is a cleavable ADC linker used in antibody drug conjugate. The Val-Cit linker was designed to be cleaved by cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Mal-amido-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker featuring a maleimide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB functional group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads, while the maleimide is used to covalently bind free thiols on the cysteine residues of proteins. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.

SPDP-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit was designed specifically be cleaved by Cathepsin B. Pyridyldithiol reactive group enables disulfide linkage with reduced cysteines and other sulfhydryl molecule, providing a stable but cleavable bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

SPDP-Val-Cit-PAB-PNP is a cleavable ADC linker featuring an SPDP group, a Val-Cit dipeptide, a para-aminobenzyl (PAB) spacer and a para-nitrophenyl (PNP) carbonate group. SPDP is a thiol-specific covalent linker which forms disulfide bonds with cysteine residues of proteins. Val-Cit-PAB is a protease-cleavable linker which is designed for efficient payload release upon proteolysis. Finally, PNP is a good leaving group which is activated towards nucleophilic attack such as from amines.

MC (C5)-Val-Cit is a cleavable ADC linker. The Val-Cit was designed to be cleaved specifically by Cathepsin B. MC is reactive with thiol moiety Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

t-butyl-octadecanedioate-NHS ester has a t-butyl ester group and an NHS ester moiety. The t-butyl group can be deprotected under acidic conditions. NHS ester can react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fmoc-Gly-Gly-Gly-OH Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.