Click Chemistry

XMD 8-92 is shown to be an extremely selective ERK5 (BMK 1) inhibitor that presents selectivity over 402 diverse kinases. XMD 8-92 shows Kd values of 80 and 190 nM for ERK5 (BMK1) and BRD4 inhibition, respectively. XMD 8-92 also inhibits DCAMKL2, PLK4 and TNK1 (Kd values are 190, 600 and 890 nM). XMD 8-92 has been shown to block growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. XMD 8-92 reduces BMK1-dependent transactivating activity of MEF2C. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

LCL-161 is a small molecule Smac mimetic that inhibits multiple inhibitor of apoptosis (IAP) family proteins. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Idasanutlin is a potent MDM2 inhibitor with an IC50 = 6 nM in binding assay and 30 nM in cancer cell proliferation assay. It induces p53 stabilisation, cell cycle arrest and apoptosis. It displays inhibition of tumor growth in the SJSA1 tumor xenograft model and also inhibits MDR-1 at high concentrations. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

6-Azido-hexanoic acid is a linker containing an azide group and a terminal carboxylic acid. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form stable amide bonds. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azido-Aca-NHS has an azide and NHS ester end group. The azide can undergo Click Chemistry reactions with alkynes, DBCO and BCN. The NHS ester can react with amine groups to form stable amide bonds. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fmoc-Ala-Ser(Psi(Me,Me)pro)-OH is a peptide linker featuring an Fmoc-protected N-terminal on an Ala-Ser dipeptide. The serine carboxylic acid is free to react with nucleophiles such as amines to form stable bonds, while the Fmoc group can be removed with piperidine to allow the primary amine to react such as in coupling with carboxylic acids or reductive amination with ketones or aldehydes. The serine in this structure features a contorted structure due to the presence of a hemiaminal ligating the alcohol with the amide. This dipeptide may have altered biochemical interactions due to this.

2,5 -Dioxo-1-pyrrolidinyl 11-azidoundecanoate is a linker containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

11-Azidoundecanoic acid is a linker containing an azide group and a terminal carboxylic acid. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form stable amide bonds. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fmoc-Gly-Gly-OH is a peptide linker. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.