Click Chemistry

Biotin-SLC is a heterobiofunctional biotin PEG linker containing a carboxylic acid group. With its uncharged, simple alkyl-chain spacer arm, this biotin compound is membrane-permeable and useful for intracellular labeling. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Biotin-SLC-NHS Ester is membrane-permeable which allows it to be used for intracellular labeling. NHS group can react efficiently with primary amino groups (-NH2) to form stable, irreversible amide bonds. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

This is a hydrazide-activated biotinylation reagent used to label glycoproteins, carbohydrate-containing compounds that have oxidizable sugars or aldehydes. Hydrazine moiety reacts with an aldehyde to form semi-permanent hydrazone bonds. The extended spacer arm helps to minimize steric hindrance. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Gambogic acid is a natural product isolated from the resin of Garcinia hurburyi tree, Gambogic acid is a potent apoptosis inducer. It binds covalently to the regulatory subunit B (SPTSSB) of the serine palmitoyltransferase complex and inhibits de novo sphingolipid biosynthesis. Reagent grade, for research purpose.

MMAE is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. Monomethyl auristatin E or MMAE is 100-1000 times more potent than doxorubicin. It is a very potent antimitotic agent that inhibits cell division by blocking the polymerization of tubulin. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fmoc-Val-Cit-PAB-PNP is a a cleavable ADC linker used in antibody drug conjugate. The Val-Cit linker was designed to be cleaved by cathepsin B. PNP group is a good leaving group when reacting with amine bearing payload. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Monomethyl auristatin F (MMAF) is an antitubulin agent that inhibits cell division by blocking the polymerization of tubulin. Because of MMAF is highly toxic, it cannot be used as a drug itself. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kdﾊ= 1011ﾊvs. 1015M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azidobutyric acid NHS ester has an azide and NHS ester end group. The azide can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The NHS ester can react with amine groups to form stable amide bonds. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.