Click Chemistry

Panobinostat (LBH589) is an HDAC (histone deactylase) inhibitor that induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Biotin-PEG4-phosphorylamino-inosine is a PEG linker that has terminal a biotin group and a Inosine 5′-monophosphate moiety. Biotin has strong binding affinity with avidin. 5′-monophosphate moiety can be used as a substrate to study the distribution, specificity, and kinetics of inosine-5′-monophosphate dehydrogenase (IMPDH). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-(Methyltetrazine-PEG3)-amido-PEG8-3,4-dithiophenolmaleimide is mainly for site-specific conjugation of a biomolecule specifically at S-S location. For example, antibody can be conjugated specifically at interchain S-S location by two step procedure; reduction of antibody by TCEP and addition the compound above, the TCO activated biomolecules such as dye, oligo, protein, enzyme, etc., can be then added to achieve the site-specific conjugates. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-Boc-4-aminobutyric Acid is a small molecule featuring a carboxylic acid and a Boc-protected amine.

BTTP is a newest generation, accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering copper loading in the catalyst formulation. Nature Communications. 5: 4981(2014). Chem Asian J., 6(10), 2796-802(2011) Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

TBTA was introduced shortly after the copper-catalyzed azide-alkyne cycloaddition reaction was discovered to mitigate thermodynamic instability of Cu(I) in aerobic media. TBTA is a water-insoluble ligand and must be first dissolved in DMSO or DMF. J Am Chem Soc., 143 (18), 6787-6791. T. R. Chan, R. Hilgraf, K. B. Sharpless, V. V. Fokin, Org. Lett. 2004, 6, 2853. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BTTES is a a next-generation, water-soluble ligand for the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) that accelerates reaction rates and suppresses cell cytotoxicity. The biocompatibility and fast kinetics of BTTES are advancements from water-insoluble TBTA and are desirable for bioconjugation in diverse chemical biology experiments. Angew. Chem. Int. Ed., 50: 8051-8056(2011) J. Am. Chem. Soc. 2010, 132, 47, 16893–16899(2010) Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BTTAA is a next-generation, water-soluble ligand for the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) that dramatically accelerates reaction rates and suppresses cell cytotoxicity. The biocompatibility and fast kinetics of BTTAA are advancements from water-insoluble TBTA and are desirable for bio conjugation in diverse chemical biology experiments. Angew. Chem. Int. Ed., 51: 5852-5856(2012) Nature Communications, 5, 4981 (2014) Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Biotin-PEG11-Gly-Gly-Gly-amine is a chemical reagent with a biotin group, a hydrophilic PEG spacer, a glycine tripeptide, and a primary amine. Biotin has applications in a broad range of biochemical techniques, particularly in affinity-based assays such as pulldown assays. Meanwhile, the amine is free to perform a variety of reactions such as coupling with carboxylic acids, reductive amination with aldehydes or ketones, or nucleophilic substitution on electron-deficient aromatic rings.