Click Chemistry

MMAF-PEG4-amine TFA salt is a PEG linker consisting of an MMAF warhead linked to a primary amine. The amine group can be linked to a number of different structures such as carboxylic acids, aldehydes, ketones, Michael acceptors, and heterocycles. The MMAF warhead is a toxin that is delivered to cells to cause apoptosis.

N-(Azido-PEG4)-L-Lyisine is a PEG linker featuring an azide ligated to the ε-amine of lysine. Azide is a click chemistry handle which readily reacts with terminal alkynes or strained cyclooctynes, while the lysine features a free amine and carboxylic acid.

1,3-Diaminopropane is a small molecule featuring two primary amines.

Alkyne-Val-Cit-PAB is a cleavable ADC linker. The Val-Cit is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potent strategy in ADC linker design. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.

THPTA is a water-soluble, very effective ligand for Cu(I)-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). It serves a dual purpose: 1) Acceleration of the CuAAC reaction by maintaining the Cu(I) oxidation state of copper sources and 2) Protection of biomolecules from oxidative damage during the labeling reaction. THPTA is a superior alternative to water-insoluble TBTA. a) J. Am. Chem. Soc. 2011, 133, 17993. b) Bioconjugate Chem. 2010, 21, 1912. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

CL2A-SN38 is a SN38 derivative with a Mal-PEG attached peptide linker, it can easily react with antibody to form an antibody-drug conjugate (ADC). SN-38 is a potent DNA Topoisomerase I inhibitor. CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A linker is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Alkyne-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potent strategy in ADC linker design. The alkyne can form triazole linkages with azide containing molecules via copper catalyzed reactions.

PEG4000 is a large PEG chemical with two free hydroxyls on both ends. These alcohol groups are open for functionalization such as by reacting with carboxylic acids and interchanging with halogens or other electrophiles. PEG linkers are highly water soluble, making this molecule a valuable building block towards more specialized applications in drug discovery.

PEG35000 is a large PEG chemical with two free hydroxyls on both ends. These alcohol groups are open for functionalization such as by reacting with carboxylic acids and interchanging with halogens or other electrophiles. PEG linkers are highly water soluble, making this molecule a valuable building block towards more specialized applications in drug discovery.