Click Chemistry

ethyl 3,4-dibromo-2,5-dioxo-2H-pyrrole-1(5H)-carboxylate is a small molecule reagent with a dibromo maleimide. The unsaturated dibromo motif is a covalent reagent for thiol groups, and may be used to label cysteine residues in proteins. The presence of two leaving groups on this molecule allows it to bind two thiols at a time.

18-(tert-Butoxy)-18-oxooctadecanoic acid) is a short linker featuring a carboxylic acid and a tert-butyl ester. Carboxylic acids can be reacted with alcohols or amines, while the tert-butyl ester can be deprotected and further connected to another molecule.

tert-Butyl Hydrogen Tetradecanedioate is a short linker featuring a carboxylic acid and a tert-butyl ester. Carboxylic acids can be reacted with alcohols or amines, while the tert-butyl ester can be selectively deprotected to allow for reactivity as a carboxylic acid to form esters or amides.

10-(tert-Butoxy)-10-oxodecanoic acid is a short linker featuring a carboxylic acid and a tert-butyl ester. Carboxylic acids can be linked with alcohols or amines, while the tert-butyl ester can be selectively deprotected to allow for reactivity as a carboxylic acid to form esters or amides.

3-azidopropan-1-amine is a small molecule featuring an azide and an amine. The amine can be utilized in a variety of reactions such as coupling with carboxylic acids or reductive amination with aldehydes or ketones, while azides can be used as click chemistry handles to react with terminal alkynes or strained cyclooctynes.

Biotin-PEG12-Gly-Gly-Gly is a cleavable PEG linker with a biotin group that can be used in the synthesis of antibody-drug conjugates. Biotin has strong binding affinity with avidin and can be used in detection, immobilization, targeting, labeling as well as nonradioactive purification. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

3-Azido-alcohol is a synthetic building block for adding an azide group with a hydroxyl handle. The azide group can react with alkyne such as BCN, DBCO, Propargyl group via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fmoc-PEG3-Val-Cit is a PEG linker containing an Fmoc-protected amine and enzymatically cleavable Val-Cit group. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic conditions to obtain the free amine which can be used for further conjugations. The Val-Cit is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potent strategy in ADC linker design.

Azide-PEG3-MMAF is a PEG linker with an azide moiety and a MMAF payload. The azide group enables Click Chemistry. MMAF is a potent tubulin polymerization inhibitor and is used as an antitumor agent.