Click Chemistry

Azido-PEG1-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azido-PEG3-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azido-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker which contains an azide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB functional group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads, while the azide is free to perform click chemistry with terminal alkynes or strained cyclooctynes such as DBCO or BCN. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.

Val-Cit-PAB-OH is a peptide cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fmoc-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Fmoc can be deprotected under basic condition. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fmoc-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate containing a cleavable Val-Cit peptide, a PABC linker and a MMAE payload. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-Boc-Biocytin is a biotin PEG linker containing a carboxylic group and Boc-protected amine. Reaction of carboxylic with primary amino (-NH2) forms stable, irreversible amide bonds. The Boc group can be deprotected under acidic condition to obtain the free amine which can be used for further conjugations. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Biocytin is a biotin-lysine complex which can be used as an intracellular marker. Primary amine can be crosslinked to proteins or molecular surfaces using EDC. Biotinylated Lysine can be used as a quenching reagent in biotin assay methods. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azido-PEG4-Ala-Ala-Asn(Trt)-PAB is a unique peptide cleavable ADC linker for antibody-drug-conjugation, Azido group is very reactive toward DBCO, BCN or other Alkyne groups, called click chemistry. The trt protecting group can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.