Click Chemistry

Azide-PEG3-Val-Cit-PAB-MMAF is a PEG linker with an azide moiety with a cleavable amino acid group and a MMAF payload. The azide group enables Click Chemistry. The Val-Cit will specifically be cleaved by Cathepsin B. MMAF is a potent tubulin polymerization inhibitor and is used as a antitumor agent.

Nutlin-3 is an inhibitor of the MDM2-p53 interaction by occuping the binding site of p53 in MDM2 and consequently prevent MDM2 binding to p53 leading to the disruption of the autoregulator feedback loop and the fostering of the p53 tumor suppressor network. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

IBT6A is a Btk kinase inhibitor. This compound is a precurser for the manufacture of ibrutinib. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

MC-Val-Cit-PAB-MMAF is a precursor of antibody drug conjugates (ADCs) with an enzymatically cleavable VAl-Cit site. The maleimide group is reactive with thiol bearing molecules. MMAF is a synthetic antineoplastic agent which may be employed as a cytotoxic payload. The Val-Cit will specifically be cleaved by Cathepsin B.

N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-quinazolin-4-amine is a quinazoline derivative that has also been used in the design, synthesis, and biological evaluation of quinazoline-phosphoramidate mustard conjugates. Reagent grade, for research purposes. Please contact us for GMP-grade inquiries.

4-Hydroxy-butyric acid tert-butyl ester is a short aliphatic linker featuring a primary alcohol and a t-butyl ester.

Suberic acid is a short aliphatic linker featuring two carboxylic acids, which can be used to react with amines or alcohols to form amides or esters respectively.

Azelaic acid is a short aliphatic linker featuring two carboxylic acids, which can be used to react with amines or alcohols to form amides or esters respectively.

Decanedioic acid is a short aliphatic linker featuring two carboxylic acids, which can be used to react with amines or alcohols to form amides or esters respectively.