Click Chemistry

20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and in the synthesis of PROTACs. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Exatecan is a structural analog of camptothecin and shows anticancer activity.

Ansamitocin P 3 is an ansamycin antibiotic with potent antitumor activity. Ansamitocin works through microtubule inhibition in eukaryotic microorganisms but has no activity against prokaryotic microorganisms. The acyl moieties at the C-3 position of ansamitocins are essential for their antifungal activities.

Auristatin F, an analogue of MMAF, is a potent cytotoxin used in antibody-drug conjugates (ADCs). As a microtubule inhibitor and vascular damaging agent (VDA), it impedes cell division by preventing tubulin polymerization.

Dov-Val-Dil-OH TFA salt is an intermediate of dolastoxin, which is a cytotoxic liner peptide and exhibits potent antitumor activity.

N-Me-L-Ala-maytansinol is a hydrophobic, cell-permeable payload that can be used to create antibody drug conjugates (ADCs).

DM1-SMCC is a drug-linker conjugate composed of the potent microtubule-disrupting agent DM1 and SMCC as a linker to make antibody drug conjugates (ADCs).

Mal-PEG8-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit linkers can be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups. PEG spacer improves the compound's aqueous solubility. PNP is a good leaving group.

Azido-PEG8-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit linkers can be cleaved by Cathepsin B. Azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry. PEG spacer improves the compound's aqueous solubility. PNP is a good leaving group.