Click Chemistry

3,4-Dibromo-Mal-PEG8-t-butyl ester is a PEG linker with a dibromomaleimide moiety and a t-butyl ester group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. Dibromo-Maleimide is sensitive to high temperature and light. The t-butyl ester can be removed under acidic conditions. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

3,4-Dibromo-Mal-PEG8-acid is a PEG linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. Dibromo-Maleimide is sensitive to high temperature and light. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Bis-sulfone-PEG8-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

I-BET-762 is cell-permeable benzodiazepine compound that binds the tandem bromodomains of BET (bromodomain and extra terminal domain). I-BET-762 binds to BRD2 (1-473), BRD3 (1-434), and BRD4 (1-477) with high affinity (Kd = 61.3, 50.5, and 55.2 nM, respectively, by ITC) and effectively competes against tetra-acetylated H4 peptide for BRD2/3/4 binding (IC50 = 32.5, 42,4, and 36.1 nM, respectively), while exhibiting little affinity toward 5 other bromodomain-containing proteins (ATAD2, BAZ2B, CREBBP, PCAF, SP140). I-BET-762 is reported to downregulate the expression of the genes which are induced by LPS, thus causing the decreased expression of LPS-inducible cytokines and chemokines. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains a a protease-sensitive Val-Cit dipeptide, and a MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.