Click Chemistry

Cy5-PEG-CH2COOH, MW 2,000 is a polyPEG reagent containing a cyanine dye with excitation/emmission maximum 649/667 nm and a free terminal carboxyl acid. Terminal carboxylic acid can react with primary amine groups in the presence of of activators (e.g. HATU) to form an amide bond. The hydophilic PEG polymer increases solubility in aqueous media.

DBCO-PEG8-MMAF is an antitubulin agent with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody.

3-Azido-7-hydroxycoumarin has the special property to become fluorescent only when it is click ligated. The formed triazole expands the electron system of the dye and enables fluorescence. Therefore, there is no background signal of the click unligated leftover dye. This dye is a valuable tool for nucleic acid labeling.

3-Azido-7-hydroxycoumarin has the special property to become fluorescent only when it is click ligated. The formed triazole expands the electron system of the dye and enables fluorescence. Therefore, there is no background signal of the click unligated leftover dye. This dye is a valuable tool for nucleic acid labeling.

Copper bromide (CuBr) is a source of a click-active copper species. In organic solvents it works optimal with TBTA as a ligand. Our CuBr is of high purity and we take especially care for its stability. In this state it is one of the most effective catalyst for click reactions. After solubilizing it is necessary to use it right away to avoid fast degradation (< 30 min).

Copper bromide (CuBr) is a source of a click-active copper species. In organic solvents it works optimal with TBTA as a ligand. Our CuBr is of high purity and we take especially care for its stability. In this state it is one of the most effective catalyst for click reactions. After solubilizing it is necessary to use it right away to avoid fast degradation (< 30 min).

If you want to perform click reactions in organic media using e.g. CuBr as catalytic source, TBTA is the right ligand to use. It speeds-up the reactions plus maintaining the Cu(I) oxidation state of the copper source to protect your biomolecules from damage and degradation.

If you want to perform click reactions in organic media using e.g. CuBr as catalytic source, TBTA is the right ligand to use. It speeds-up the reactions plus maintaining the Cu(I) oxidation state of the copper source to protect your biomolecules from damage and degradation.

If you want to perform click reactions in organic media using e.g. CuBr as catalytic source, TBTA is the right ligand to use. It speeds-up the reactions plus maintaining the Cu(I) oxidation state of the copper source to protect your biomolecules from damage and degradation.