Click Chemistry

The water-soluble ligand THPTA is a very efficient additive for click reactions using CuSO4 as catalyst. It speeds-up the reactions plus maintaining the Cu(I) oxidation state of copper source to protect your biomolecules from damage and degradation.

Azidoacetyl-Val-Cit-PAB-OH serves as a peptide cleavable ADC linker employed in the development of antibody-drug conjugates (ADCs). The azide on the N-terminus can react with BCN, DBCO, alkyne to form a triazole linkage.

DBCO-S-S-NHS ester functions as a cleavable reagent containing NHS ester which can directly and efficiently react with amine-bearing molecules and DBCO which participates in copper-free Click Chemistry with azides. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME, and TCEP.

DXD, an Exatecan derivative that is a potent DNA topoisomerase I inhibitor, may be used as a payload in HER2-targeting antibody drug conjugates (ADCs).

N-Ethyl-N',N'-dimethylpropane-1,3-diamine is a compound comprised of a secondary and a tertiary amine. Reagent grade, for research use only.

AR-42, also called OSU-HDAC42, is a powerful inhibitor of histone deacetylase (HDAC). It effectively stops HDAC activity, leading to increased acetylation of histone H3, α-tubulin, and an up-regulation of p21. HDAC inhibitors focus on HDAC enzymes, and they are applied in cancer research. Reagent grade, for research purpose.

4-Azido-L-phenylalanine

N-(Propargyl-PEG2)-DBCO-PEG3-NHS ester is a PEG linker with a terminal NHS ester to perform facile reactions with amine groups of molecules as well as a propargyl to react with azides to form a triazole. The DBCO can participate in copper-free Click Chemistry reactions.

Phenylmethyl N-(10-bromodecyl)carbamate