Click Chemistry

3-Azidopropionic Acid contains an azide moiety and carboxylic acid group. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkyne groups. The terminal carboxylic acid group can react with primary amine groups in the presence of activators such as EDC or HATU to form stable amide bonds. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DSPE-PEG-Biotin, MW 5,000 is a biotinylation amphiphile. DSPE-PEG has been widely studied for encapsulation of therepeutics drug. The biotin enables the polymer to have strong binding to streptavidin and avidin. Reagent grade, for research purpose.

Monomethyl auristatin D (MMAD) is a potent tubulin inhibitor. Synonyms: Demethyldolastatin 10; Monomethylauristatin D; MMAD. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; it is a synthetic analog of dolastatin 10. Auristatin E is a highly potent antimitotic agent. Auristatin E inhibits tubulin polymerization(1). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Ansamitocin P-3 (AP-3) is an active and potent anti-tumor maytansinoid, which is produced by Actinosynnema spp. Ansamitocin P-3 showed potent cytotoxicity against the human solid tumor cell lines A-549, HT-29. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Maytansine is a potent microtubule-targeted compound that inhibits proliferation of cells at mitosis. Antibody-maytansinoid conjugates consisting of maytansinoids (DM1 and DM4) attached to tumor-specific antibodies have shown promising clinical results The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their association with tubulin or microtubules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Mertansine, also called DM1 is a thiol-containing maytansinoid for therapeutic purposes. It can be attached to a monoclonal antibody through reaction of the thiol group with a maleimide linker to create an antibody-drug conjugate (ADC). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Ravtansine (DM4) is a chemical derivative of maytansine which is used as a cytotoxic component of antibody-drug conjugates. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DSPE-PEG8-propargyl is a PEG linker with attached DSPE and propargyl groups. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG linker increases the water solubility of the overall compound allowing for the delivery of the drug. The hydrophilic PEG linker increases the water solubility of the compound. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.