Results for Click Chemistry ( 996 )
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Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit linkers can be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups. PEG space improve compound's aqueous solubility. PNP is a good leaving group. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable ADC linker which contains a maleimide, a hydrophilic PEG spacer, a valine-citrulline (Val-Cit) dipeptide, a para-aminobenzyl (PAB) spacer and a para-nitrophenyl (PNP) carbonate group. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues in proteins while the PNP carbonate acts as a highly activated leaving group which may be used to react with amines. The use of cleavable linkers in the development of ADCs allows a medicinal chemist to decide the point where the drug payload is released to the cell. Val-Cit-PAB linkers are cleaved by cytoplasmic peptidases.
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3-Azidopropanoic acid NHS ester is an azidopropanoic acid linker that contains an NHS ester group. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkyne, DBCO and BCN. The NHS ester can react with other primary amines to label proteins and antibodies. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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3-Azidopropanoic acid-PFP ester is an azidopropanoic acid linker that contains an activated PFP ester. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to form triazole linkages. The activated PFP ester can react with amine groups to form stable amide bonds. They are also less susceptible toward undergoing hydrolysis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Cabazitaxel attaches to the N-terminal amino acids of the beta-tubulin subunit, enhancing microtubule polymerization and preventing disassembly, which is crucial for its role as a payload in antibody-drug conjugates (ADCs). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Paclitaxel, a microtubule polymer stabilizer and antimicrotubule agent, is utilized in antibody-drug conjugates (ADCs). It binds to the inner surface of microtubules, preventing depolymerization and promoting tubulin subunit assembly into stable microtubules. This interaction induces cell death through apoptosis, mitotic arrest, and autophagy. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.