Compound Libraries

Activity: Comprises 81 highly selective inhibitors of various kinases . Function/Pharmacology: The IntelliScreen™ Highly Selective Kinase Inhibitor Library represents a targeted collection of compounds chosen for their specificity. Notorious for their lack of specificity, some of the oldest and most familiar inhibitors are among the most indiscriminate, inhibiting an array of kinases from multiple kinase families. While occasionally this promiscuity can be beneficial in biological applications, it tends to be an obstacle in pathway or target identification. This library is designed to offer researchers a compact collection of inhibitors deliberately chosen for their high selectivity for an individual target. This high degree of selectivity increases reliability, reduces ambiguity, and helps to limit the amount of additional testing required after screening.

Activity: Comprises 171 modulators of various aspects of cancer cell metabolism . Function/Pharmacology: Concentrations vary based on effective concentrations… see library compound list.

- A unique collection of 2818 approved drugs for high throughput screening (HTS) and high content screening (HCS); - All compounds collected in this library are drugs approved by Food and Drug Administration (FDA), the European Medicine Agency (EMA), or National Medical Products Administration (NMPA), etc; - An effective tool for discovering new with old drugs and new drug target identification; - Covers various research areas, such as Cancer, Cardiovascular disease, GPCR/G protein, Neuroscience, Membrane Transporter/Ion Channel, Microbiology & Virology, Immunology/Inflammation, Tyrosine Kinase/Adaptors, etc. - More detailed compound information with structure, target, activity, IC50 value, and brief introduction; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality;

- 3215 compounds from marketed drugs for high throughput screening (HTS) and high content screening (HCS); - All compounds collected in this library are drugs approved by FDA, EMA, PMDA, NMPA, etc. or included in pharmacopoeia such as USP, BP, JP, etc.; - An effective tool for discovering new with old drugs and new drug target identification; - Covers various research areas, such as Cancer, Cardiovascular disease, Neuroscience, Immunology/Inflammation, respiratory system disease, etc. - More detailed compound information with structure, target, activity, IC50 value, and brief introduction; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality.

- A unique collection of 507 protease and proteasome inhibitors for research in chemical genomics, and drug screening; - Targets include proteasome, DPP-4, Serine protease, cysteine protease, MMP, Aspartic proteinases, etc; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality;

- A unique collection of 142 microtubule-targeted compounds can be used in HTS and HCS; - Detailed compound information with structure, target, and biological activity description; - NMR and HPLC/LCMS validated to ensure high purity and quality.

- Quantity：80 well-chosen unique AMPK-targeted small molecules； - Detailed compound information with structure, target, IC50, and biological activity description； - NMR and HPLC/LCMS validated to ensure high purity and quality； - All compounds are in stock；

- Quantity: well-chosen 1090 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new drugs; - Targets include HDAC, SIRT, HAT, and HMT, etc.; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description, providing reference for your experimental design; - NMR and LCMS/HPLC validated to ensure high purity and quality. - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality;

- A unique collection of 610 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling; - Effective tool for studying cell growth, proliferation, and apoptosis; - Targets include AKT, AMPK, mTOR, PI3K, ATR/ATM, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality;