Results for Lipids & Polymers ( 10120 )
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Azido-PEG11-t-butyl ester is a click chemistry linker containing an azide (N3) and a t-butyl ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group is reactive toward alkyne, BCN, DBCO via Click Chemistry . The t-butyl protected carboxyl group can be deprotected under acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Propargyl-PEG12-methane is a PEG linker that can react with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to form a stable triazole linkage. The PEG chain enhances the solubility of the molecule in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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t-Boc-Aminooxy-PEG2-CH2CO2H is a short PEG linker. The terminal carboxylic acid cis reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc-protected amine can be deprotected under mild acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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BP Lipid 106 is an amino ionizable lipid with ester bonds located at C7 relative to nitrogen. The ethanolamine head can effectively enhance mRNA encapsulation while ester bonds improve tissue clearance. The primary lipid tail contains 11 carbons. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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LP01 is a biodegradable ionizable lipid which can reduce liver bioaccumulation significantly compared to levels observed in ionizable lipids such as MC3. This lipid can form nanoparticles that can encapsulate and deliver siRNA, mRNA, DNA or small molecules into cells. The pKa is 6.1. Reagent grade, for research use only.
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BP Lipid 216 is an amine lipid which has both ester bonds located adjacent to C7 relative to the nitogen amine. The head contains ethanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.