Lipids & Polymers

LNP-102 is a lipid nanoparticle (LNP) formulated with SM-102, DSPC, Cholesterol, and DMG-PEG2000. LNP-102 is formulated at optimal molar ratio for efficient delivery of mRNA-based vaccines.

m-PEG3-triethoxysilane is a PEG linker containing a triethoxysilane moiety. Triethoxysilane is commonly used for surface modifications. The hydrophilic PEG linkers increase the water solubility of a compound in aqueous media. The water solubility properties of the PEG linkers are enhanced with longer PEG chains. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-PEG-acid, MW 1,000 is a linear heterobifunctional PEG derivative. The cyclooctyne DBCO is used for bioorthogonal reaction with azide molecule via Cu-free Click Chemistry (SPAAC). Reagent grade, for research purpose.

Azido-PEG5-triethoxysilane is a PEG linker containing azido and triethoxysilane moieties. The azide can be used for copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The triethoxysilane moiety is used for surface modification. The hydrophilic PEG linkers increase the water solubility properties of compounds in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Biotin-PEG3-amine is reactive with NHS ester or carboxylic acid in the presence of EDC or HATU. PEG3 increases aqueous solubility of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the binding to avidin molecules.

Biotin-PEG3-amine is reactive with NHS ester or carboxylic acid in the presence of EDC or HATU. PEG3 increases aqueous solubility of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the binding to avidin molecules.

TCO-PEG2-acid is a click chemistry linker containing a TCO (trans-cycloctene) and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators such as EDC. TCO reagent is highly reactive with tetrazine in an inverse electron demand Diels Alder (IEDDA) reaction followed by a retro-DA reaction. The hydrophilic PEG spacer increases solubility in aqueous media.

N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester is a protected multifunction linker. The azide group enables PEGylation via Click Chemistry. Boc and the t-butyl protected carboxyl group can be deprotected under mild acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azido-PEG3-CH2CO2Me is a crosslinker containing an azide group and methyl ester. The azide group enables Click Chemistry reactions. The hydrophilic PEG spacer increases solubility in aqueous media. Methyl ester can be hydrolyzed under strong basic condition. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.