Lipids & Polymers

1,2-Epoxytetradecane is a chemical reagent featuring an epoxy group on a C14 chain. The epoxy group undergoes ring opening in the presence of nucleophiles to form a branched structure containing a secondary alcohol. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

C12-200 is a branched-chain ionizable lipidoid with five hydroxyl groups. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA, siRNA, or self-amplifying RNA (saRNA). The hydroxyl groups enables further derivatization or replacement with other reactive functional groups. Reagent grade, for research use only.

DMG-PEG 2000, also called 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, is used for liposome preparation. DMG-PEG 2000 has become known for lipid nanoparticle (LNP) preparation for siRNA (small interfering RNA) delivery in the COVID-19 vaccine development. Reagent grade, for research purpose.

DOTMA is one of the first cationic lipid used for gene transfection. It is an effective transfection agent in vitro and in vivo. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome. Reagent grade, for research use only.

DOPE, also known as 1,2-Dioleoyl-sn-glycero-3-PE or 1,2-DOPE, is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. 1,2-DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery. Reagent grade, for research use only.

Methyltetrazine-PEG7-amine HCl salt is an aqueous soluble amine-containing click chemistry crosslinker. Methyl group improves the stability and hydrophilic PEG spacer increases water-solubility. The amine (NH2) group is reactive with carboxylic acid containing molecule in the presence of reagnet such as EDC or HATU. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene) Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-PEG12-NHS Ester is a monodisperse PEG linker which enable free copper click chemistry with N3 group. NHS ester moiety can react specifically and efficiently with primary amines to form a covalent amide bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

4-Hydroxy-thalidomide is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTACs. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

dBET1 is a PROTAC compound comprised of BET bromodomain antagonist (+)-JQ1 linked to a cereblon E3 ubiquitin ligase ligand. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.