Lipids & Polymers

N-(acid-PEG3)-N-bis(PEG4-NHS ester) is a branched PEG linker with two terminal NHS ester groups which can react with amine-bearing moeities and a terminal caboxylic group which can react with amines in the presence of coupling reagent (e.g. HATU). The PEG spacer enhances water-solubility.

N-(Benzyloxy carbonyl-PEG3)-N-bis(PEG4-NHS ester) is a branched PEG linker containing two terminal NHS ester groups which can react with amine-containing molecules. The PEG arm imparts hydrophilicity.

N-(Benzyloxy carbonyl-PEG3)-N-bis(PEG4-acid) is a branched PEG linker with two terminal carboxylic acid groups that can react with amines in the presence of coupling agents such as HATU. The PEG linker improves the aqueous solubility of the compound.

DSPE-PEG8-azide is a heterobifunctional PEG linker. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The azide group can perform copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN.

N-t-Boc-Aminooxy-PEG4-N-(PEG2-Propargyl) is a click chemistry crosslinker. The propargyl group is reactive with azide-containing compounds or biomolecules through copper catalyzed Click Chemistry to yield a stable triazole linkage. t-Boc-aminooxy can be deprotected under mild acidic conditions. The hydrophilic PEG linker improves solubility in aqueous media.

N-(Azido-PEG4)-N-(PEG4-t-butyl ester) acts as a PEG linker possessing a free azide to react with BCN, DBCO, alkyne via Click Chemistry, a central amine, and a t-butyl group that can be deprotected under acidic conditions.

Azido-PEG-t-butyl ester, MW 2,000 is a polyPEG comprised of a 2k PEG polymer, azide group which can react with DBCO, BCN, alkyne via Click Chemistry to yield a stable triazole linkage, and a t-butyl ester group that can be deprotected under acidic conditions.

BP Lipid 377 is an ionizable amino lipid comprised of three linoleic acid tails and an N,N-dimethylamine head group four carbon atoms in length. This lipid may be used in the generation of lipid nanoparticles (LNPs) for mRNA and drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

H-Gly-Gly-Phe-OH is a tripeptide linker that may be used in the creation of antibody drug conjugates (ADCs). The N-terminal of the glycine tripeptide is free to perform a variety of reactions such as couplings with carboxylic acids or NHS esters.