Lipids & Polymers

N-(Amine-PEG4)-N-bis(PEG4-N-Boc) serves as a branched PEG linker comprised of a terminal amine group that is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The two N-Boc groups can be deprotected to allow for reactions with carboxylic acids and other carbonyl groups like aldehydes or ketones.

Azide-PEG-acid, MW 2,000 is a polyPEG linker with a 2k PEG polymer for enhanced hydrophilicity, azide group for click reactions with BCN, DBCO, alkyne, and carboxylic acid group for further derivatization.

Azido-PEG-t-butyl ester, MW 5,000 is a polyPEG reagent comprised of a 5k PEG polymer for enhanced hydrophilicity, azido group for click reactions with BCN, DBCO, alkyne, and t-butyl group that can be deprotected under acidic conditions.

BP Lipid 382 is a novel biodegradable lipid featuring one branched lipid tail, one adipic acid-based lipid chain, and a short four carbon chain functionalized with an ionizable 3-hydroxy azetidine head group. The head group is designed to provide dual polar and ionizable functionality. This compound may be used in the formulation of lipid nanoparticles (LNPs) for mRNA delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Pomalidomide-amido-bis-benzoate-acid is a synthetic compound used in PROTAC technology, combining a Pomalidomide-based cereblon ligand with a bis-benzoate linker.

Pomalidomide-amido-bis-benzoate-aminooxy

m-PEG12-SPDP is a thiol reactive PEG linker used in PEGylation of proteins or peptides or other thiol molecules. The PEG12 spacer enhances the solubility of PEG siginificantly in an aqueous solution.

Azide-PEG-acid, MW 5,000 is a polyPEG reagent with an azide group with a terminal carboxylic acid. The azide group can react with alkyne, BCN, DBCO via Click Chemistry. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU). The 5k PEG polymer increases the water-solubility of the molecule.

PEG 5,000