Lipids & Polymers

Methyltetrazine-PEG3-Iodoacetamido comprises of a methyltetrazine that enables fast click chemistry with TCO (trans-cycloctene), and the methyl group enhances the stability of the tetrazine moiety. The iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.

Methyltetrazine-PEG3-Iodoacetamido consists of a click chemistry methyltetrazine handle that speedily reacts with TCO (trans-cycloctene), and the methyl group improves the tetrazine's stability. The iodoacetamido moiety may be employed to bind covalently with the thiol group of cysteine to prevent disulfide bridges in proteins.

Biotin-PEG4-sulfo-Maleimide is comprised of a terminal biotin and a maleimide group that will specifically and efficiently react with thiols to form thioether bonds.

DSPE-Rhodamine B is a fluorescent lipid containing a DSPE phospholipid and a Rhodamine B fluorophore.

cKK-E15 serves as an ionizable lipid. It plays a crucial role in creating lipid nanoparticles (LNPs).

SM-102 N-oxide is an impurity that may be present in commercial formulations of SM-102.

Lipid AX4 serves as an ionizable lipid in lipid nanoparticles (LNPs) for in vivo mRNA delivery.

C12-113 functions as an ionizable cationic lipidoid. Researchers have harnessed its properties by combining it with other lipids to formulate lipid nanoparticles (LNPs). These LNPs serve as a vehicle for delivering mRNA encoding the spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice.

C12-SPM is a lipidoid characterized by a branched-chain structure containing polyamine moieties. Researchers have employed it in conjunction with other lipids to create lipid nanoparticles (LNPs). These LNPs serve as carriers for delivering small interfering RNA (siRNA) that specifically targets the host protein kinase C-related kinase 2 (PRK2).