Lipids & Polymers

A cholesterol-drug conjugate serving as the prodrug of Doxorubicin (Chol-Dox). Self-assemblies of Chol-Dox and PEG-succinate derivatives have been formulated for drug delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

An oxidized form of squalene serving as an intermediate for the biosynthesis of sterols. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

A multichargeable cholesterol carbamate derivative that has been used in conjunction with DOPE for the formulation of cationic liposomes to deliver siRNA. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-PEG4-Amido-tri-(PEG6-TCO)-methane serves as a clickable branched linker consisting of a terminal DBCO commonly used for copper-free Click Chemistry reactions and three terminal TCO groups that readily react with tetrazine-containing compounds. The PEG4 chain linking the DBCO to the amido groups and the PEG6 linker connecting the TCO groups both enhance the solubility of the overall molecule in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

SGK3-PROTAC1 is a degradation-inducing compound that combines the 308-R SGK inhibitor with the VH032 VHL binding ligand in a PROTAC conjugate. This compound is designed to facilitate the degradation of SGK3 through targeted interactions.

BODIPY FL VH032 stands as a high-affinity VHL fluorescent probe. It proves invaluable in time-resolved fluorescence resonance energy-transfer (TR-FRET) assays, offering a robust tool for the efficient high-throughput identification and characterization of VHL ligands.

VH032, a VHL ligand, plays a crucial role in recruiting the von Hippel-Lindau (VHL) protein. Functioning as an inhibitor of VHL/HIF-1α interactions, VH032 exhibits a Kd that underscores its efficacy in PROTAC-mediated processes.

HaloPROTAC3 represents a fusion of E3 ligands, a linker spanning 16 atoms in length, and a degrading agent targeting fusion proteins with the HaloTag.

HaloPROTAC-E facilitates the reversible degradation of two proteins, SGK3 and VPS34, both localized in endosomes. The compound demonstrates remarkable selectivity by specifically inducing degradation of the Halo-tagged endogenous VPS34 complex.