Lipids & Polymers

Boc-Gly-PEG3-amine works as a PEG linker featuring an amino group and a Boc-protected amino group. Amino (NH2) group is reactive with carboxylic acids, and activated NHS esters. The Boc group can be deprotected under mild acidic conditions to form the free amine. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 423 is a symmetric polar lipid featuring a two unsaturated oleic acid tails and an azido group for click chemistry. This compound features biodegradeable ester and amide linkages may be used for bioconjugation and surface modification applications, or as a useful synthetic scaffold for novel lipids. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 424 is a symmetric polar lipid featuring a two unsaturated oleic acid tails and a DBCO group for click chemistry. This compound may be used for bioconjugation and surface modification applications, or as a useful synthetic scaffold for novel lipids. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Benzyloxy carbonyl-PEG5-acid functions as a linker with a benzyl protecting group and a carboxylic acid. The carboxylic acid can undergo reactions with primary amines via activators (EDC or HATU). The benzyl protecting group can be removed via hydrogenolysis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-O-TBDMS-7-O-(Azido-PEG4)-Paclitaxel

bis-Mes-PEG, MW 5,000 represents a homobifunctional polyPEG reagent containing two methanesulfonyls, which act as good leaving groups. The polymer can be used for nucleophilic SN2 substitution reactions. The 5k polyPEG enhances the hydrophilicity of the compound.

Val-Cit-PAB-MMAE is a derivatized linker-payload that can be used in the creation of antibody-drug conjugates (ADCs). It contains a cathepsin-cleavable Val-Ala dipeptide and an MMAE payload, which is a synthetic antineoplastic agent that can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. The azide moiety can react with alkyne, BCN, and DBCO via Click Chemistry to yield a stable triazole linkage. The PEG spacer enhances the water-solubility of the compound and may aid in optimizing DMPK properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

An ionizable lipid featuring a two biodegredable ester linkages to unsaturated oleic acid tails. Additional features include a core hydroxyl group to promote hydrogen-bonding with neighboring lipids. This compound may be used in the formulation of lipid nanoparticles (LNP's) for delivery applications. Reagent grade, for research purpose.

AMCA-PEG1-NHS ester is the AMCA dye linker containing a NHS ester group and a hydrophilic PEG spacer arm. The NHS ester allows the dye to react with primary amines and the hydrophilic PEG spacer arm increases water solubility as well as membrane permability. This dye is used for protein and peptide labeing. The structure is similar to commercial AMCA-X-SE with better solubility. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.