Lipids & Polymers

PC Azido-PEG23-OH is a long, photocleavable PEG linker with an azido that can react with alkynes, DBCO, and BCN via copper-catalyzed Click Chemistry reactions. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp. The PEG polymer bolsters the hydrophilicity of the molecule. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

NH2-PEG-acid, TFA salt, MW 5,000 constitutes a bifunctional PEG polymer consisting of a primary amine that is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses. The carboxylic acid can react with primary amine groups in the presence of activators such as HATU. The 5k polyPEG linking the two groups improves the solubility of the molecule in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

3,5-bis(2-methylheptanoate)-benzaldehyde

BP Lipid 435 is an analog of the ionizable lipid LP01 and features a PEG6-azide linker for click chemistry, bioconjugation, or surface modification applications. This lipid may also be used as a novel component in lipid nanoparticle (LNP) formulations. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Pomalidomide-PEG8-propargyl serves as a PROTAC linker featuring a Pomalidomide-based cereblon ligand that incorporates an E3 ligase ligand. The terminal propargyl is reactive with azide-bearing compounds or biomolecules via copper-catalyzed azide-alkyne Click Chemistry. The PEG8 chain improves the water-solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DSPE-PEG-Gly-Gly-Gly TFA salt, MW 2,000 functions as an active ester reactive polyPEG phospholipid containing a Gly-Gly-Gly tripeptide which can be used for conjugation. The 2k PEG polymer greatly improves the water solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

PC Mal-PEG4-OH functions as a photocleavable PEG linker including a maleimide moiety which is thiol-reactive between pH 6.5 to 7.5. The PEG4 spacer increases the aqueous solubility of the compound and assists in fine-tuning DMPK properties. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azido-PEG1-Val-Cit-PAB-PNP constitutes a cleavable ADC linker used in antibody-drug conjugates (ADCs). The Val-Cit linker was designed to be cleaved by cathepsin B. The PNP group is a good leaving group when reacting with amine-bearing payloads. Additionally, the azido group reacts with DBCO, BCN, or linear alkyne groups via click chemistry. The PEG unit enhances the water-solubility of the molecule.

Lipid CAD9 is a multichargeable cationionc lipioid featuring a piperazine core and biodegradable aldehyde-based tails. Lipid CA9 has been identified as an effective component of lipid nanoparticle formulations for targeted mRNA delivery (Nat Commun 2024, 15, 1884). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.