Lipids & Polymers

DSDMA is a fully saturated ionizable ether lipid featuring a dimethylamino head group and stearyl aliphatic tails. This compound may be used in the formulation of lipid nanoparticles (LNP's) for mRNA delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 440 is an analog of the ionizable lipid LP01 whose key feature is the introduction of an iso- methyl branched fatty acid tail. This alteration has been designed to investigate the effect on the dynamics of lipid nanoparticle as methyl branched fatty acids have been reported to affect the fluidity and structure of lipid bilayers (J. Phys. Chem. B 2014, 118, 48, 13838–13848). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DSPE-PEG-Hz-mal, MW 2,000 is a polyPEG compound with DSPE and maleimide groups. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic polyPEG increases the water solubility of the overall compound allowing for the delivery of the drug. Maleimide groups can react with thiol groups between pH 6.5 to 7.5.

DBCO-PEG10-amine constitutes a bifunctional PEG linker with DBCO and amine on either side, respectively. The DBCO group can be employed for copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The PEG spacer increases the solubility in aqueous media.

An aliphatic amine featuring two oleyl fatty acid tails and a polar ethanolamine head group. This useful lipid scaffold may be further functionalized at the reactive free hydroxyl or used as a functional component for lipid nanoparticles. Reagent grade, for research purpose. Please contact us for GMP-grade.

An aliphatic amine featuring two saturated stearyl aliphatic tails and a polar ethanolamine head group. This useful lipid scaffold may be further functionalized at the reactive free hydroxyl or used as a functional component for solid lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade.

A multichargeable lipid featuring a bis-stearyl aliphatic amine tail group and a dimethylamine butanoate head group. This compound may be formulated into lipid nanoparticles for drug delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade.

Oleyl Mesylate is a derivative of Oleyl Alcohol, commonly used in various formulations for delivery systems due to its functional properties. The mesyl group serves as a good leaving group for nucleophilic substitution reactions.

DBCO-PEG9-amine represents a bifunctional PEG linker with DBCO group for copper-free catalyzed click chemistry with azides and amine group for reacting with NHS-ester to form an amide bond.