Lipids & Polymers

SPDP-PEG4-Azide is a PEG linker comprised of an SPDP crosslinker, which is reactive with thiol-containing molecules to form disulfide bonds, and an azide which reacts with DBCO, BCN, and linear alkynes through click chemistry.

BP Lipid 446 is a multichargeable lipid featuring three biodegrade amide tails, three amine spaces eight (8) carbon atoms long, and a central piperazine head group. This compound may be formulated into lipid nanoparticles for drug delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade.

Fluorescein-PEG7-Methyltetrazine is a xanthene dye with excitation/emission maximum of 494/517 nm and a terminal tetrazine group. The terminal methyltetrazine enables fast click reactions with TCO (trans-cycloctene). Hydrophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. Reagent grade, for research use only. Please contact us for GMP-grade inquiries.

Methyltetrazine-PEG4-PFP ester operates as a heterobifunctional PEG linker including methyltetrazine, a click chemistry handle used to efficiently react with trans-cyclooctenes (TCO), and PFP ester, an amine-reactive ester that is less susceptible toward hydrolysis compared to NHS ester. The hydrophilicity of the molecule is elevated via the PEG4 spacer.

DBCO-PEG8-amine represents a PEG linker with an azide-reactive DBCO group that participates in copper-free catalyzed chemistry and amine that can be used to derivatize carboxyl groups via activators (e.g. HATU) or NHS ester groups directly.

Bis-sulfone-PEG4-DBCO constitutes a PEG linker with a sulfone and DBCO end group. The sulfone group can be conjugated with thiol groups of proteins. The terminal DBCO can react with azides through copper-free catalyzed click chemistry. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media.

PC Mal-PEG3-biotin functions as a photocleavable biotinylated reagent containing biotin, which has a strong binding with avidin or streptavidin for protein labeling or purification, and maleimide group, which will react with a thiol group. The PEG spacer imparts solubility in aqueous media. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp.

A useful synthetic scaffold consisting of two cis-2-noneyl esters and a free hydroxyl head group which may be further functionalized into an ionizable head group. Reagent grade, for research purpose. Please contact us for GMP-grade.

Methyltetrazine-PEG4-Sulfo DBCO constitutes a heterobifunctional PEG linker with a methyltetrazine click chemistry handle that rapidly ligates to trans-cyclooctene (TCO) groups on target molecules and DBCO click chemistry handle that undergoes copper-free reactions with azides. The PEG arm improves the solubility of the compound in aqueous media.