Lipids & Polymers

Mal-PEG12-MMAE acts as a linker attached to a payload, where the maleimide group will react with a thiol group to form a covalent bond, and the MMAE payload serves as a synthetic antineoplastic agent for targeted therapeutics. The PEG12 units elevate the molecule's water solubility.

3,7,11-trimethyldodecyl 6-bromohexanoate

m-PEG2-alcohol

3,4-Dibromo-Mal-PEG2-Acid constitutes a PEG linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. Dibromo-Maleimide is sensitive to high temperature and light. The carboxylic acid can react with primary amines in the presence of coupling agents such as EDC and HATU. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

PC Biotin-PEG8-NHS carbonate ester is useful for introducing a biotin moiety to amine-containing biomolecules directly and efficiently. The hydrophilic PEG arm provides better solubility to the labeled molecules in aqueous media. Captured biomolecules can be efficiently photoreleased using near-UV, low intensity lamp (e.g. 365 nm lamp at 1-5 mW/cm2).

Bis-PEG5-Methyltetrazine represents a bifunctional PEG linker where methyltetrazine enables a fast click reaction with TCO (trans-cycloctene).

Picolyl azide-PEG4-NHS ester is a bifunctional PEG linker comprised of a picolyl moiety that assists with a copper-chelating system within its structure, lowering the amount of copper catalyst required in the CuAAC reaction for the azide and an NHS ester that directly and efficiently reacts with amine-bearing moieties. The PEG4 chain improves the compound's water solubility.

BP Lipid 449 is a novel analog of the ionizable lipid LP01 whose key feature is the introduction of a bis cyclopropyl fatty acid tail. This alteration has been designed to investigate the effect on the dynamics of lipid nanoparticles as cyclopropane fatty acids have been reported to affect the fluidity and structure of lipid bilayers in response changes in temperature and pH (J. Phys. Chem. B 2014, 118, 48, 13838–13848). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-PEG12-TFP ester acts as a bifunctional PEG linker with a DBCO group that can be used for copper-free Click Chemistry reactions and TFP ester, which is less susceptible to undergo hydrolysis compared to NHS ester. The solubility of the compound in aqueous media is elevated via the PEG linkage.