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Phosphatidylethanol (16:0 LysoPEth) is formed primarily in the liver by transphosphatidylation of phosphatidylcholine (PC) by phospholipase D in the presence of ethanol. PEth is a long-lived circulating ethanol biomarker with forensic and biomedical applications. LysoPEth is formed either through loss of the sn-1 acyl chain or transphosphatidylation of LysoPC. It is also reported to be a biomarker of alcohol consumption.