Lipids & Polymers

C3-K2-E14 is a multi-ionizable amino-lipid featuring a central tertiary amine with two identical brranches and an n-propyl group. Each branch features a propanamide linking to a branched amine, each with two C14 arms and a hydroxyl. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery.

Acid-PEG4-C2-Boc, a linker compound based on polyethylene glycol (PEG) and alkyl/ether, is utilized in the synthesis of PROteolysis TArgeting Chimeras (PROTACs) for inhibiting the mechanistic Target of Rapamycin (mTOR)[1].

Dde Biotin-PEG4-DBCO is a PEG-based linker for PROTACs that connects two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

m-PEG4-Hydrazide is a PEG-based linker for PROTACs, joining two essential ligands crucial for PROTAC molecule formation, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

BCN-PEG3-VC-PFP ester, a three-unit PEG ADC linker, is cleavable and commonly used in the synthesis of antibody-drug conjugates (ADCs) [1].

DBCO-PEG4-Desthiobiotin is a polyethylene glycol (PEG) derivative utilized as a linker for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

DBCO-SS-PEG4-Biotin, a cleavable, mid-functional ADC linker with a 4-unit PEG moiety, is used in the synthesis of antibody-drug conjugates (ADCs)[1].

N-(Azide-PEG3)-N'-(PEG4-NHS ester)-Cy5 is a polyethylene glycol (PEG)-derived PROTAC linker, used in the synthesis of PROTACs [1].

PC Azido-PEG23-NHS carbonate ester functions features an amine-reactive NHS ester connected to a terminal azide via a photocleavable linker and PEG linker. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp. The azido can participate in copper-catalyzed Click Chemistry reactions with alkynes, DBCO, and BCN. The NHS labels the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-bearing molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.