Lipids & Polymers

PC Azido-PEG7-NHS carbonate ester constitutes a photocleavable PEG linker featuring an azido moiety for copper-catalyzed click chemistry with alkyne, DBCO, BCN, and NHS carbonate ester to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp

Lulizumab pegol (BMS-931699) is an anti-CD28 antibody antagonist that inhibits T-cell proliferation, offering potential therapeutic applications for kidney transplantation and autoimmune disease research [1].

Azido-PEG3-maleimide is a PEG-based PROTAC linker used primarily for the synthesis of PROTACs[1] and also functions as a cleavable 3-unit PEG ADC linker in the synthesis of antibody-drug conjugates (ADCs)[2].

endo-BCN-PEG8-acid, a PEG-based linker, is pivotal for PROTAC molecules, connecting two essential ligands and facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Biotin-PEG-Biotin (MW 1000) is a PEG-derived PROTAC linker utilized in PROTAC synthesis [1].

Gly-Gly-Gly-PEG4-DBCO is a degradable ADC linker containing 4 units of PEG, which can be used to synthesize antibody-conjugated active molecules (ADCs).

Mal-amido-PEG12-acid is a PEG-based linker for PROTACs, facilitating the formation of PROTAC molecules by connecting two essential ligands and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Propargyl-PEG3-amine (Propargyl-PEG3-NH2) is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

Lipid CP-LC-0741 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo, with no signs of toxicity.