Lipids & Polymers

Lipid CP-LC-1447 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo. Moreover, using a typical LNP formulation (IL/Ch/DOPE/PEG: 50/38.5/10/1.5), it has shown to induce specific spleen targeting much more efficiently that other commercial alternatives through IV injection, with no signs of toxicity.

Propargyl-PEG-acid, MW 2,000 constitutes a polyPEG linker with a 2k PEG polymer for enhanced hydrophilicity and propargyl group that can participate in copper catalyzed azide-alkyne Click Chemistry. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-PEG4-tri-(carboxyethoxymethyl)-methane constitutes a branched PEG linker that includes DBCO for copper-free click reactions and three terminal carboxyl groups for reacting with primary amines in the presence of activators like HATU. The PEG linkers bolster the hydrophilicity of the molecule. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Certolizumab pegol (Certolizumab) is a recombinant, humanized monoclonal antibody fragment modified with polyethylene glycol (PEG), selectively targeting and neutralizing tumor necrosis factor-alpha (TNF-α). This compound is utilized in research for rheumatoid arthritis and Crohn's disease [1] [2].

Mal-amido-PEG9-amine, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

The compound 3,4-Dibromo-Mal-PEG8-acid is a PEG-based PROTAC linker employed for PROTAC synthesis[1].