Lipids & Polymers

80-O18 is an ionizable lipid used to generate lipid nanoparticles (LNPs) for delivery of proteins. A GFP-Cre recombinase fusion protein encapsulated in 80-O18 LNPs was delivered to the cytosol of HeLa-HGM cells. Cytosolic delivery was measured by a chloroalkane penetration assay.

OC2-K3-E10 is an ionizable lipid for delivery of mRNA in lipid nanoparticles (LNPs). OC2-K3-E10 LNPs delivered Firefly luciferase mRNA when injected intramuscularly in mice and resulted in comparable levels of luminescence as SM-102 LNPs. LNPs were also able to deliver Cas9 mRNA and sgRNA into genetically modified mice. LNPs containing OC2-K3-E10 were able to encapsulate four-fold more mRNA copies per particle compared to SM-102.

PPZ-A10 is an ionizable lipid used for formulating lipid nanoparticles to deliver RNA in vitro and in vivo. PPZ-A10 LNPs preferentially delivered Cre mRNA to liver and spleen immune cells when injected intravenously into mice at concentrations as low as 0.3 mg/kg. PPZ-A10 LNPs containing RNA to generate chimeric antigen receptor macrophages were injected into a hepatocellular carcinoma mouse model resulting in decreased tumor burden and increased survival.

The linker-degradable ionizable lipid (LDIL) 4A3-SCC-10 possesses superior endosomal escape and rapid mRNA release abilities thanks to its unique GSH-responsive cone-shaped architecture. Lipid nanoparticles (LNPs) of 4A3-SCC-10 showed improved mCherry mRNA delivery in livers by 87-fold compared to DLin-MC3-DMA in vivo. 4A3-SCC-10 also demonstrated improved mRNA delivery in vivo compared to its parent counterpart without a disulfide bond or control counterpart with a disulfide bond in the tail.

Lipid Nanoparticles (LNPs) made from Cholesterol-Amino-Phosphate (CAP) CAP2 can deliver traditional mRNA and self-amplifying RNA (saRNA) encoding DNA Meiotic Recombinase 1 (Dmc1) protein in spermatocytes. A single injection of CAP2 LNPs–saRNA can produce Dmc1 protein for an extended period and restore spermatid production in the Dmc1 gene knockout mouse model.

Oleyl alcohol, also known as cis-9-octadecen-1-ol, is an unsaturated fatty alcohol. It is a colorless oil, mainly used in cosmetics.

1-Hydroxyoctadecane is an endogenous metabolite.

1-Heptadecanol, with the chemical identifier CAS number 1454-85-9, is a fatty alcohol featuring a linear chain of 17 carbon atoms and a terminal hydroxyl group (C17H36O). This colorless and odorless compound possesses a moderate melting point and is sparingly soluble in water, while it readily dissolves in organic solvents. Derived from natural sources or synthesized chemically, 1-Heptadecanol finds versatile applications. It is commonly utilized in the formulation of cosmetics, personal care products, and pharmaceuticals, thanks to its emollient properties that contribute to moisturization and conditioning effects. Furthermore, it may be employed in the fragrance and flavor industry to enhance sensory attributes in various consumer goods. In industrial contexts, 1-Heptadecanol functions as a valuable chemical intermediate for synthesizing other compounds. Its adaptability in different formulations makes it a significant component across diverse industries, playing a pivotal role in th

2-((2-(2-(2-methoxyethoxy)ethoxy)ethoxy)methyl)oxirane is a PEG linker with an epoxide ring and four ethylene glycol units linked together.