Lipids & Polymers

6-Amino-1-hexanol

S-undecyl 6-bromohexanethioate is an aliphatic linker featuring a bromide, a C6 spacer, and a thioester linked to a C11 chain.

undecyl 6-(2-hydroxyethylamino)hexylcarbamate is an amino lipid featuring an ethanolamine head, a hexyl spacer and a carbamate linking it to an undecyl chain. This molecule is ionizable at its secondary amine, where it can also be alkylated to expand this structure.

N-benzyl-PEG4-N-Boc

(6Z,16Z)-12-((Z)-dec-4-enyl)docosa-6,16-dien-11-yl 5-bromopentanoate is a lipid analogue of CL1 featuring a bromide head group and an ester linking to the branched polyunsaturated tail. This compound may be used to develop lipids for lipid nanoparticle-based drug delivery.

N-(acid-PEG3)-N-bis(PEG4-NHS ester) is a branched PEG linker with two terminal NHS ester groups which can react with amine-bearing moeities and a terminal caboxylic group which can react with amines in the presence of coupling reagent (e.g. HATU). The PEG spacer enhances water-solubility.

N-(Benzyloxy carbonyl-PEG3)-N-bis(PEG4-NHS ester) is a branched PEG linker containing two terminal NHS ester groups which can react with amine-containing molecules. The PEG arm imparts hydrophilicity.

N-(Benzyloxy carbonyl-PEG3)-N-bis(PEG4-acid) is a branched PEG linker with two terminal carboxylic acid groups that can react with amines in the presence of coupling agents such as HATU. The PEG linker improves the aqueous solubility of the compound.

DSPE-PEG8-azide is a heterobifunctional PEG linker. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The azide group can perform copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN.