Lipids & Polymers

PROTAC RAR Degrader-1 consists of a binding group for IAP, a linker, and a ligand specific to retinoic acid receptors (RAR). This compound functions as a degrader of RAR, utilizing the ubiquitin-proteasome system for targeted degradation. The use of cIAP1-based degradation inducers, known as SNIPERs, enhances the specificity of this approach in protein modulation.

PROTAC BET Degrader-3 consists of ligands that link von Hippel-Lindau and bromodomain and extraterminal (BET) proteins. This structure facilitates targeted protein degradation through the ubiquitin-proteasome system, leveraging the functional properties of its components for effective cellular interactions.

ARD-1676 is an orally bioavailable PROTAC designed for degrading the androgen receptor (AR). It comprises a ligand that targets AR and a cereblon ligand, facilitating the degradation process through the ubiquitin-proteasome system. This compound demonstrates effective AR degradation both in vitro and in vivo, contributing to the inhibition of tumor growth in mouse xenograft models.

OARV-771 is a derivative of ARV-771, which is a potent PROTAC targeting bromodomain and extraterminal (BET) proteins, utilizing the von Hippel-Lindau E3 ligase for targeted degradation. This compound features selective binding affinity for various BRD proteins, demonstrating its potential utility in research focused on modulating BET protein functions.

Thalidomide-NH-CBP/p300 ligand 2 is a PROTAC designed to induce the degradation of CBP and p300 through targeted protein degradation mechanisms.

PROTAC KRAS G12C degrader-2 is a bifunctional molecule that modulates K-Ras protein hydrolysis. It combines a cereblon-targeting ligand with a KRAS-binding moiety to facilitate targeted degradation of KRAS.

Dovitinib RIBOTAC is a selective RNA degrader designed to target and cleave pre-miR-21, offering enhanced potency and specificity in RNA degradation.

PROTAC HER3 Degrader-8 is a bifunctional molecule designed to induce the degradation of HER3 protein in vitro and in cellular assays, useful for investigating pathways involving HER family proteins.

SJF-0628 is a PROTAC designed to selectively degrade mutant BRAF proteins. It targets specific BRAF variants, making it useful for studying conditions linked to RAF protein aggregation, accumulation, or persistent activation.