Lipids & Polymers

PROTAC EGFR Degrader 3 is a selective molecule designed to target EGFR for degradation, exhibiting strong cellular activity, particularly in H1975 and HCC827 cells. It operates through a lysosome-mediated degradation pathway for EGFR mutants.

HG-7-85-01-NH2 consists of an ABL inhibitor moiety connected to an IAP ligand through a linker, facilitating the formation of a SNIPER compound. This structural arrangement enhances targeted interactions and functional activity.

DB0614 is a PROTAC that incorporates a Cereblon ligand to selectively and effectively degrade NEK9. This compound demonstrates the capability to target and degrade various kinases, including ABL1, ABL2, BLK, and several others involved in diverse signaling pathways. The structural components facilitate precise protein interactions, making DB0614 a valuable tool for investigating conditions linked to dysregulated kinase activity.

PROTAC EED degrader-2 is a compound that employs von Hippel-Lindau as the E3 ligase to facilitate the targeted degradation of the EED subunit within the polycomb repressive complex 2 (PRC2). This degrader functions as an inhibitor of PRC2, effectively disrupting its activity through selective engagement with the EED component.

PROTAC FKBP Degrader-3 is a targeted protein degrader that consists of a binding group for FKBP, a linker, and a von Hippel-Lindau binding moiety. This structure enables efficient degradation of FKBP, highlighting its potential for precise protein regulation.

MS4077 is a PROTAC designed to target anaplastic lymphoma kinase (ALK), featuring a Cereblon ligand for effective protein degradation. Its structural configuration allows for strong binding affinity to ALK, facilitating targeted protein modulation.

SR-1114 is a novel PROTAC that selectively degrades the ENL protein through a CRBN-dependent mechanism. Its structural design enables efficient and rapid targeting of ENL in various cell lines, facilitating studies on protein turnover and regulatory pathways.

CFT1946 is an orally active bifunctional degradation activating compound designed for selective degradation of the BRAF V600E mutant through a CRBN-based mechanism. Its structural features enable it to effectively target various BRAF mutations, including G469A, G466V, and the p61-BRAF V600E splice variant, making it valuable for investigating tumor biology.

RSS0680 is a bifunctional compound designed for the targeted degradation of various kinases. Its structural composition facilitates the degradation of multiple kinases, including AAK1, CDK1, CDK2, CDK4, and others, making it useful for exploring conditions associated with dysregulated kinase activity.