Lipids & Polymers

PROTAC BRD9 Degrader-6 is a highly potent molecule that targets BRD9 for degradation, making it useful for studying disorders related to the BAF complex. Its structure incorporates functional groups designed for efficient protein degradation.

α1A-AR Degrader 9c is a selective and reversible PROTAC molecule that targets the α1A adrenergic receptor for proteasomal degradation. Its functional groups are optimized for degrading α1A-AR and inhibiting cell proliferation, making it useful for studying receptor-related processes in prostate cell models.

PROTAC CYP1B1 Degrader-1, a derivative of α-naphthoflavone, is designed to selectively degrade CYP1B1, reducing cytochrome P450-mediated resistance. Its structure effectively targets CYP1B1 while showing selectivity over CYP1A2, making it useful for studying CYP1B1-overexpressing systems.

PROTAC EGFR Degrader 3 is a selective molecule designed to target EGFR for degradation, exhibiting strong cellular activity, particularly in H1975 and HCC827 cells. It operates through a lysosome-mediated degradation pathway for EGFR mutants.

HG-7-85-01-NH2 consists of an ABL inhibitor moiety connected to an IAP ligand through a linker, facilitating the formation of a SNIPER compound. This structural arrangement enhances targeted interactions and functional activity.

DB0614 is a PROTAC that incorporates a Cereblon ligand to selectively and effectively degrade NEK9. This compound demonstrates the capability to target and degrade various kinases, including ABL1, ABL2, BLK, and several others involved in diverse signaling pathways. The structural components facilitate precise protein interactions, making DB0614 a valuable tool for investigating conditions linked to dysregulated kinase activity.

PROTAC EED degrader-2 is a compound that employs von Hippel-Lindau as the E3 ligase to facilitate the targeted degradation of the EED subunit within the polycomb repressive complex 2 (PRC2). This degrader functions as an inhibitor of PRC2, effectively disrupting its activity through selective engagement with the EED component.

PROTAC FKBP Degrader-3 is a targeted protein degrader that consists of a binding group for FKBP, a linker, and a von Hippel-Lindau binding moiety. This structure enables efficient degradation of FKBP, highlighting its potential for precise protein regulation.

MS4077 is a PROTAC designed to target anaplastic lymphoma kinase (ALK), featuring a Cereblon ligand for effective protein degradation. Its structural configuration allows for strong binding affinity to ALK, facilitating targeted protein modulation.