Lipids

Phosphatidylinositol 4 5-bisphosphate diC8 (PI(4 5)P2 diC8) is a synthetic purified dioctanoyl PI(4 5)P2.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues and is also a substrate for class I phosphoinositide 3-kinase (PI3-K).Alternate Names: D-myo-Phosphatidylinositol 4 5-bisphosphate Dioctanoyl Phosphatidylinositol 4 5-bisphosphate PtdIns(4 5)P2 C8 PI(4 5)P2 C8 or PIP2Bulk discounts available please email echelon@echelon-inc.com for information.Publications Powered by Bioz See more details on Bioz1) Jenco J. M. A. Rawlingson et al. (1998). "Regulation of phospholipase D2: selective inhibition of mammalian phospholipase

DOPE-PEG-Amine, MW 1,000 is an amino phospholipid polyPEG. The polymer can self-assemble in water to form micelles and can be used to prepare liposomes or nanoparticles for drug delivery applications. Reagent grade, for research purpose.

Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid formed by phosphorylation of sphingosine by sphingosine kinases. S1P binds to five G-protein coupled receptors designated S1P1-5 leading to cell proliferation motility and has a role in regulation cell shape. In addition S1P acts as an intracellular mediator in a receptor-independent manner regulating cell survival and Ca2+ homeostasis. Sphingosine 1-phosphate fluorescein is a S1P analog with natural erythro stereochemistry labeled at the terminus of the alkyl chain with fluorescein. Powered by Bioz See more details on Bioz

Phosphatidylethanol (PEth) is formed primarily by transphosphatidylation of phosphatidylcholine (PC) by phosphlipase D. Most PEth (about 75%) is incorporated into erythrocyte membranes and is one of the longest-lived circulating EtOH metabolite yet identified. 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol-d5 (d5-POPEth) has a fully deuterated ethanol headgroup and can be used as a mass spectrometry standard.

Cardiolipin (CL) is an important component in prokaryotic and in eukaryotic inner mitochondrial membrane. In humans CL is made by cardiolipin synthase from phosphatidylglycerol and cytidinediphosphatediacylglycerol. Due to its four acyl chains and small head group CL can organize into domains which can be proton sinks fill cavities at protein interfaces stabilize protein oligomers and participate in high-curvature membrane regions. Autoantibodies to CL have been found in patients with anti-phospholipid syndrome and lupus.The free acid is being discontinued please use the ammonium salt as a replacement (cat# L-C161) Powered by Bioz See more details on Bioz

DSPE-PEG-Amine, MW 2,000 is a PEG polymer containing DSPE and amine end groups. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG increases the water solubility of the overall compound allowing for the delivery of the drug. The amine group can react with activated NHS ester to form a stable amide bond. Reagent grade, for research purpose.

Cholesterol is a steroid component featured heavily in cell membranes. It is universally found in animal cells and is readily synthesized de novo from mevalonic acid. It can be used to selectively target drugs and probes towards cell membranes. It also is a key component of lipid nanoparticles, which see growing use in modern drug and vaccine delivery.

1 2-Dioleoyl-sn-glycero-3-phosphoethanol (DOPEth) is a form of phosphatidylethanol (PEth) which is formed primarily by transphosphatidylation of phosphatidylcholine (PC) by phospholipase D. Most PEth (about 75%) is incorporated into erythrocyte membranes and is one of the longest-lived circulating EtOH metabolite yet identified. DOPEth is a one of five most abundant naturally occurring PEth species.

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol (POPEth) is a form of phosphatidylethanol (PEth) which is formed primarily by transphosphatidylation of phosphatidylcholine (PC) by phospholipase D. Most PEth (about 75%) is incorporated into erythrocyte membranes and is one of the longest-lived circulating EtOH metabolite yet identified. POPEth is a one of five most abundant naturally occurring PEth species.